Double stranded oligonucleotide compositions and methods related thereto
The present disclosure provides double stranded oligonucleotides, compositions, and methods related thereto. The disclosure encompasses the insight of structural elements of double stranded oligonucleotides, such as base sequences, chemical modifications (e.g., modifications of sugars, bases and/or...
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| creator | MARAPPAN, SUBRAMANIAN TRIPATHI, SNEHRATA LIU WEI BEDEKAR, MUGDHA VARTI PADIKAR, VINOD IWAMOTO NAOKI APPONI LUCIANO H VARGHESE, CHANDRA BUTLER DAVID CHARLES DONNELL KANDASAMY, PARCHAMUTHU |
| description | The present disclosure provides double stranded oligonucleotides, compositions, and methods related thereto. The disclosure encompasses the insight of structural elements of double stranded oligonucleotides, such as base sequences, chemical modifications (e.g., modifications of sugars, bases and/or inter-nucleotide linkages) or patterns thereof, and/or stereochemical modifications (e.g., modifications of glycosides, bases and/or inter-nucleotide linkages). Stereochemistry (chiral inter-nucleotide linkage) of a skeleton chiral center and/or a mode thereof can produce significant influences on oligonucleotide characteristics and activity, such as RNA interference (RNAi) activity, stability, delivery, and the like. The disclosure also provides methods of treating diseases, such as in RNA interference, using the provided double stranded oligonucleotide compositions.
本披露提供了双链寡核苷酸、组合物和与其相关的方法。本披露涵盖以下认识：双链寡核苷酸的结构元件，例如碱基序列、化学修饰(例如，糖、碱基和/或核苷酸间键联的修饰)或其模式，和/或立体化学(例如，骨架手性中心的立体化学(手性核苷酸间键联))和/或其模式可以对寡核苷酸特性和活性产生显著影响，例如RNA干扰 |
| format | Patent |
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本披露提供了双链寡核苷酸、组合物和与其相关的方法。本披露涵盖以下认识：双链寡核苷酸的结构元件，例如碱基序列、化学修饰(例如，糖、碱基和/或核苷酸间键联的修饰)或其模式，和/或立体化学(例如，骨架手性中心的立体化学(手性核苷酸间键联))和/或其模式可以对寡核苷酸特性和活性产生显著影响，例如RNA干扰</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230331&DB=EPODOC&CC=CN&NR=115885042A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230331&DB=EPODOC&CC=CN&NR=115885042A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARAPPAN, SUBRAMANIAN</creatorcontrib><creatorcontrib>TRIPATHI, SNEHRATA</creatorcontrib><creatorcontrib>LIU WEI</creatorcontrib><creatorcontrib>BEDEKAR, MUGDHA</creatorcontrib><creatorcontrib>VARTI PADIKAR, VINOD</creatorcontrib><creatorcontrib>IWAMOTO NAOKI</creatorcontrib><creatorcontrib>APPONI LUCIANO H</creatorcontrib><creatorcontrib>VARGHESE, CHANDRA</creatorcontrib><creatorcontrib>BUTLER DAVID CHARLES DONNELL</creatorcontrib><creatorcontrib>KANDASAMY, PARCHAMUTHU</creatorcontrib><title>Double stranded oligonucleotide compositions and methods related thereto</title><description>The present disclosure provides double stranded oligonucleotides, compositions, and methods related thereto. The disclosure encompasses the insight of structural elements of double stranded oligonucleotides, such as base sequences, chemical modifications (e.g., modifications of sugars, bases and/or inter-nucleotide linkages) or patterns thereof, and/or stereochemical modifications (e.g., modifications of glycosides, bases and/or inter-nucleotide linkages). Stereochemistry (chiral inter-nucleotide linkage) of a skeleton chiral center and/or a mode thereof can produce significant influences on oligonucleotide characteristics and activity, such as RNA interference (RNAi) activity, stability, delivery, and the like. The disclosure also provides methods of treating diseases, such as in RNA interference, using the provided double stranded oligonucleotide compositions.
本披露提供了双链寡核苷酸、组合物和与其相关的方法。本披露涵盖以下认识：双链寡核苷酸的结构元件，例如碱基序列、化学修饰(例如，糖、碱基和/或核苷酸间键联的修饰)或其模式，和/或立体化学(例如，骨架手性中心的立体化学(手性核苷酸间键联))和/或其模式可以对寡核苷酸特性和活性产生显著影响，例如RNA干扰</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyzEOwjAQBVE3FAi4w3IAJAJESosCKBUVfWTsT2LJ8Vrezf1JwQGopnmzNt2N53cEiRabPDxxDAOn2UWwBg9yPGWWoIGT0EJogo7shQqi1WXQEQXKW7P62CjY_box-8f91XYHZO4h2TokaN8-q6pumvp4OV3P_5gvFMw1Mw</recordid><startdate>20230331</startdate><enddate>20230331</enddate><creator>MARAPPAN, SUBRAMANIAN</creator><creator>TRIPATHI, SNEHRATA</creator><creator>LIU WEI</creator><creator>BEDEKAR, MUGDHA</creator><creator>VARTI PADIKAR, VINOD</creator><creator>IWAMOTO NAOKI</creator><creator>APPONI LUCIANO H</creator><creator>VARGHESE, CHANDRA</creator><creator>BUTLER DAVID CHARLES DONNELL</creator><creator>KANDASAMY, PARCHAMUTHU</creator><scope>EVB</scope></search><sort><creationdate>20230331</creationdate><title>Double stranded oligonucleotide compositions and methods related thereto</title><author>MARAPPAN, SUBRAMANIAN ; TRIPATHI, SNEHRATA ; LIU WEI ; BEDEKAR, MUGDHA ; VARTI PADIKAR, VINOD ; IWAMOTO NAOKI ; APPONI LUCIANO H ; VARGHESE, CHANDRA ; BUTLER DAVID CHARLES DONNELL ; KANDASAMY, PARCHAMUTHU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115885042A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MARAPPAN, SUBRAMANIAN</creatorcontrib><creatorcontrib>TRIPATHI, SNEHRATA</creatorcontrib><creatorcontrib>LIU WEI</creatorcontrib><creatorcontrib>BEDEKAR, MUGDHA</creatorcontrib><creatorcontrib>VARTI PADIKAR, VINOD</creatorcontrib><creatorcontrib>IWAMOTO NAOKI</creatorcontrib><creatorcontrib>APPONI LUCIANO H</creatorcontrib><creatorcontrib>VARGHESE, CHANDRA</creatorcontrib><creatorcontrib>BUTLER DAVID CHARLES DONNELL</creatorcontrib><creatorcontrib>KANDASAMY, PARCHAMUTHU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARAPPAN, SUBRAMANIAN</au><au>TRIPATHI, SNEHRATA</au><au>LIU WEI</au><au>BEDEKAR, MUGDHA</au><au>VARTI PADIKAR, VINOD</au><au>IWAMOTO NAOKI</au><au>APPONI LUCIANO H</au><au>VARGHESE, CHANDRA</au><au>BUTLER DAVID CHARLES DONNELL</au><au>KANDASAMY, PARCHAMUTHU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Double stranded oligonucleotide compositions and methods related thereto</title><date>2023-03-31</date><risdate>2023</risdate><abstract>The present disclosure provides double stranded oligonucleotides, compositions, and methods related thereto. The disclosure encompasses the insight of structural elements of double stranded oligonucleotides, such as base sequences, chemical modifications (e.g., modifications of sugars, bases and/or inter-nucleotide linkages) or patterns thereof, and/or stereochemical modifications (e.g., modifications of glycosides, bases and/or inter-nucleotide linkages). Stereochemistry (chiral inter-nucleotide linkage) of a skeleton chiral center and/or a mode thereof can produce significant influences on oligonucleotide characteristics and activity, such as RNA interference (RNAi) activity, stability, delivery, and the like. The disclosure also provides methods of treating diseases, such as in RNA interference, using the provided double stranded oligonucleotide compositions.
本披露提供了双链寡核苷酸、组合物和与其相关的方法。本披露涵盖以下认识：双链寡核苷酸的结构元件，例如碱基序列、化学修饰(例如，糖、碱基和/或核苷酸间键联的修饰)或其模式，和/或立体化学(例如，骨架手性中心的立体化学(手性核苷酸间键联))和/或其模式可以对寡核苷酸特性和活性产生显著影响，例如RNA干扰</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Double stranded oligonucleotide compositions and methods related thereto |
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