T cell modified by fusion chimeric antigen receptor of targeted expression DSG3 surface antigen cell and application of T cell

The invention provides a T cell modified by a fusion chimeric antigen receptor of a targeted expression DSG3 surface antigen cell and application of the T cell, and belongs to the technical field of gene engineering. The chimeric antigen receptor is at least one of (1) a chimeric antigen receptor fo...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG TONGCUN, SUN FAN, CUI YETING, LYU MENGQING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a T cell modified by a fusion chimeric antigen receptor of a targeted expression DSG3 surface antigen cell and application of the T cell, and belongs to the technical field of gene engineering. The chimeric antigen receptor is at least one of (1) a chimeric antigen receptor for targeted expression of DSG3 surface antigen cells; (2) expressing DSG3 surface antigen cells in a targeted manner, and simultaneously secreting IL-15SA fusion protein, IL-36 gamma or a recruitment chimeric antigen receptor of CXCL11; (3) carrying out targeted expression on DSG3 surface antigen cells, and simultaneously carrying out membrane expression on an infiltrated chimeric antigen receptor of CCR8 or CXCR6; and (4) a fusion chimeric antigen receptor which carries out targeted expression on DSG3 surface antigen cells, secretes IL-15SA fusion protein, IL-36 gamma or CXCL11 and carries out membrane expression on CCR8 or CXCR6 at the same time. The invention provides a method which is more efficient and less in