Synthesis method of lipid containing amido bond

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of lipid containing amido bonds. The synthesis method comprises the following steps: mixing carboxylic acid, amine, a base catalyst and chloromethylsulfonyl fluoride, and reacting to prepare the lipid containing the amido bond. According to the synthesis method disclosed by the invention, carboxylic acid, amine, a base catalyst and chloromethylsulfonyl fluoride are mixed and reacted to prepare the amido bond-containing lipid, the conditions are mild and are lower than the phase transition temperature and the hydrolysis temperature of most liposomes, the yield is remarkably improved, and the synthesis method is more suitable for lipid synthesis. Compared with a traditional coupling reagent catalytic amidation method, the synthesis method is more economical and efficient, purification is easy, and the yield is high. 本发明属于有机合成技术领域，公开了一种含酰胺键脂质的合成方法。该合成方法，包括以下步骤：将羧酸、胺、碱催化剂、氯甲基磺酰氟混合，反应，制得含酰胺键脂质。本发明的合成方法将羧酸、胺、碱催化剂、氯甲基