VTE risk assessment model based on polygene mutation, construction method and application

The invention provides a VTE risk assessment model based on polygene mutation characteristics, a construction method and application, the model is based on one or a combination of more of obtained 35 characteristic genes significantly related to whether VTE is sick or not, the characteristic genes are SERPINC1, F5, AQP9, LRRC6, KIF6, DHX34, REXO1, TPBGL, MFAP1, RTKN2, ASPN, MKI67, KIAA1522, FGFR4, PGLYRP4, CCBL2, ATP5S, ENDOG, DMBT1, DBR1, PNPLA7, TBC1D24, CSF1R, GSTA5, ERICH6, C7orf25, GALK1, TMEM143, OXR1 The technical problem that in the prior art, an existing evaluation model is difficult to discover rare mutation associated with some pathopoiesia is solved. 本发明提供一种基于多基因突变特征的VTE风险评估模型、构建方法及应用，该模型基于获得的与VTE是否患病显著相关的35个特征基因中的一个基因或多个基因组合，特征基因为：SERPINC1、F5、AQP9、LRRC6、KIF6、DHX34、REXO1、TPBGL、MFAP1、RTKN2、ASPN、MKI67、KIAA1522、FGFR4、PGLYRP4、CCBL2、ATP5S、ENDOG、DMBT1、DBR1、PNPLA7、TBC1D24、CSF1R、GSTA5、ERICH6、C7orf25、GALK1、TMEM143、OXR1、SETD5、AQP7、ERMAP、ZNF831、ENOSF1、GPR142。本发明解决了现有技术中已有的评估模型存在对某些致病相关联的罕见突变难以发现的技术问题。