Allyl alcohol derivative and application thereof in protein modification
The invention provides an allyl alcohol derivative and application thereof in preparation of a drug conjugate for site-specific modification of protein or polypeptide N terminal. According to the invention, a complex formed by a metal palladium compound and a phosphine ligand is used as a catalyst,...
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| creator | LIN ZENG LIU BO WANG YONGQIN LIU CHAOXI HUANG WEI LU MENGRU LUO CAILI |
| description | The invention provides an allyl alcohol derivative and application thereof in preparation of a drug conjugate for site-specific modification of protein or polypeptide N terminal. According to the invention, a complex formed by a metal palladium compound and a phosphine ligand is used as a catalyst, and an allyl alcohol derivative is used as an allyl palladium precursor to modify the N-terminal of polypeptide and protein, so that the novel polypeptide or protein N-terminal conjugate is prepared. The method is mild in condition, wide in applicability, high in efficiency and good in selectivity. According to the method, a biological orthogonal group can be introduced into the N-terminal of the antibody, and the antibody drug conjugate is prepared by utilizing a biological orthogonal reaction, or the antibody drug conjugate is prepared by utilizing an allyl alcohol derivative containing a drug structure in one step.
本发明提供了烯丙醇衍生物及其在制备定点修饰蛋白或多肽N端的药物偶联物中的应用。本发明利用金属钯化合物与膦配体形成的配合物为催化剂，以烯丙醇衍生物为烯丙基钯前体实现对多肽、蛋白N端的修饰，制备得到新 |
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本发明提供了烯丙醇衍生物及其在制备定点修饰蛋白或多肽N端的药物偶联物中的应用。本发明利用金属钯化合物与膦配体形成的配合物为催化剂，以烯丙醇衍生物为烯丙基钯前体实现对多肽、蛋白N端的修饰，制备得到新</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230307&DB=EPODOC&CC=CN&NR=115746089A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230307&DB=EPODOC&CC=CN&NR=115746089A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIN ZENG</creatorcontrib><creatorcontrib>LIU BO</creatorcontrib><creatorcontrib>WANG YONGQIN</creatorcontrib><creatorcontrib>LIU CHAOXI</creatorcontrib><creatorcontrib>HUANG WEI</creatorcontrib><creatorcontrib>LU MENGRU</creatorcontrib><creatorcontrib>LUO CAILI</creatorcontrib><title>Allyl alcohol derivative and application thereof in protein modification</title><description>The invention provides an allyl alcohol derivative and application thereof in preparation of a drug conjugate for site-specific modification of protein or polypeptide N terminal. According to the invention, a complex formed by a metal palladium compound and a phosphine ligand is used as a catalyst, and an allyl alcohol derivative is used as an allyl palladium precursor to modify the N-terminal of polypeptide and protein, so that the novel polypeptide or protein N-terminal conjugate is prepared. The method is mild in condition, wide in applicability, high in efficiency and good in selectivity. According to the method, a biological orthogonal group can be introduced into the N-terminal of the antibody, and the antibody drug conjugate is prepared by utilizing a biological orthogonal reaction, or the antibody drug conjugate is prepared by utilizing an allyl alcohol derivative containing a drug structure in one step.
本发明提供了烯丙醇衍生物及其在制备定点修饰蛋白或多肽N端的药物偶联物中的应用。本发明利用金属钯化合物与膦配体形成的配合物为催化剂，以烯丙醇衍生物为烯丙基钯前体实现对多肽、蛋白N端的修饰，制备得到新</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBwzMmpzFFIzEnOz8jPUUhJLcosSyzJLEtVSMxLUUgsKMjJTAby8_MUSjJSi1Lz0xQy8xQKivJLUoF0bn5KZhpUnoeBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCan5qWWxDv7GRqampuYGVhYOhoTowYA2OE01g</recordid><startdate>20230307</startdate><enddate>20230307</enddate><creator>LIN ZENG</creator><creator>LIU BO</creator><creator>WANG YONGQIN</creator><creator>LIU CHAOXI</creator><creator>HUANG WEI</creator><creator>LU MENGRU</creator><creator>LUO CAILI</creator><scope>EVB</scope></search><sort><creationdate>20230307</creationdate><title>Allyl alcohol derivative and application thereof in protein modification</title><author>LIN ZENG ; LIU BO ; WANG YONGQIN ; LIU CHAOXI ; HUANG WEI ; LU MENGRU ; LUO CAILI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115746089A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>LIN ZENG</creatorcontrib><creatorcontrib>LIU BO</creatorcontrib><creatorcontrib>WANG YONGQIN</creatorcontrib><creatorcontrib>LIU CHAOXI</creatorcontrib><creatorcontrib>HUANG WEI</creatorcontrib><creatorcontrib>LU MENGRU</creatorcontrib><creatorcontrib>LUO CAILI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIN ZENG</au><au>LIU BO</au><au>WANG YONGQIN</au><au>LIU CHAOXI</au><au>HUANG WEI</au><au>LU MENGRU</au><au>LUO CAILI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Allyl alcohol derivative and application thereof in protein modification</title><date>2023-03-07</date><risdate>2023</risdate><abstract>The invention provides an allyl alcohol derivative and application thereof in preparation of a drug conjugate for site-specific modification of protein or polypeptide N terminal. According to the invention, a complex formed by a metal palladium compound and a phosphine ligand is used as a catalyst, and an allyl alcohol derivative is used as an allyl palladium precursor to modify the N-terminal of polypeptide and protein, so that the novel polypeptide or protein N-terminal conjugate is prepared. The method is mild in condition, wide in applicability, high in efficiency and good in selectivity. According to the method, a biological orthogonal group can be introduced into the N-terminal of the antibody, and the antibody drug conjugate is prepared by utilizing a biological orthogonal reaction, or the antibody drug conjugate is prepared by utilizing an allyl alcohol derivative containing a drug structure in one step.
本发明提供了烯丙醇衍生物及其在制备定点修饰蛋白或多肽N端的药物偶联物中的应用。本发明利用金属钯化合物与膦配体形成的配合物为催化剂，以烯丙醇衍生物为烯丙基钯前体实现对多肽、蛋白N端的修饰，制备得到新</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Allyl alcohol derivative and application thereof in protein modification |
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