Small sitagliptin-metformin sustained release tablet and preparation method thereof
The invention provides a small sitagliptin-metformin sustained release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations containing organic effective components. The metformin sustained-release tablet comprises a protective layer, a sitaglipti...
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| creator | XU CHENGMIAO LUO JINWEN LI SONGXIAN LIU MEILING JIANG LIJIAN JIN HAO ZHOU YUANHAO HE LI LI XIAOWEN |
| description | The invention provides a small sitagliptin-metformin sustained release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations containing organic effective components. The metformin sustained-release tablet comprises a protective layer, a sitagliptin quick-release layer, a sustained-release coating layer and a metformin tablet core from outside to inside, and sitagliptin phosphate is coated on the outer layer of the metformin sustained-release tablet core to form the sitagliptin layer in a film-controlled sustained-release mechanism in a solution form. When the sitagliptin-metformin sustained-release tablet is used as the sitagliptin-metformin sustained-release tablet, the mass can be reduced by 15-39%, and the supply of small preparation mass is realized.
本申请提供一种小型西格列汀-二甲双胍缓释片及其制备方法，属于含有机有效成分的药物制剂品技术领域。从外至内分别为保护层、西格列汀速释层、缓释包衣层和二甲双胍片芯，所述磷酸西格列汀以膜控型缓释机制，采用溶液形式上药包衣于二甲双胍缓释片芯外层形成西格列汀层。将本申请作为西格列汀-二甲双胍缓释片使用，可实现质量下降15-39%，实现小制剂质量的供应。 |
| format | Patent |
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本申请提供一种小型西格列汀-二甲双胍缓释片及其制备方法，属于含有机有效成分的药物制剂品技术领域。从外至内分别为保护层、西格列汀速释层、缓释包衣层和二甲双胍片芯，所述磷酸西格列汀以膜控型缓释机制，采用溶液形式上药包衣于二甲双胍缓释片芯外层形成西格列汀层。将本申请作为西格列汀-二甲双胍缓释片使用，可实现质量下降15-39%，实现小制剂质量的供应。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230228&DB=EPODOC&CC=CN&NR=115715768A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230228&DB=EPODOC&CC=CN&NR=115715768A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XU CHENGMIAO</creatorcontrib><creatorcontrib>LUO JINWEN</creatorcontrib><creatorcontrib>LI SONGXIAN</creatorcontrib><creatorcontrib>LIU MEILING</creatorcontrib><creatorcontrib>JIANG LIJIAN</creatorcontrib><creatorcontrib>JIN HAO</creatorcontrib><creatorcontrib>ZHOU YUANHAO</creatorcontrib><creatorcontrib>HE LI</creatorcontrib><creatorcontrib>LI XIAOWEN</creatorcontrib><title>Small sitagliptin-metformin sustained release tablet and preparation method thereof</title><description>The invention provides a small sitagliptin-metformin sustained release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations containing organic effective components. The metformin sustained-release tablet comprises a protective layer, a sitagliptin quick-release layer, a sustained-release coating layer and a metformin tablet core from outside to inside, and sitagliptin phosphate is coated on the outer layer of the metformin sustained-release tablet core to form the sitagliptin layer in a film-controlled sustained-release mechanism in a solution form. When the sitagliptin-metformin sustained-release tablet is used as the sitagliptin-metformin sustained-release tablet, the mass can be reduced by 15-39%, and the supply of small preparation mass is realized.
本申请提供一种小型西格列汀-二甲双胍缓释片及其制备方法，属于含有机有效成分的药物制剂品技术领域。从外至内分别为保护层、西格列汀速释层、缓释包衣层和二甲双胍片芯，所述磷酸西格列汀以膜控型缓释机制，采用溶液形式上药包衣于二甲双胍缓释片芯外层形成西格列汀层。将本申请作为西格列汀-二甲双胍缓释片使用，可实现质量下降15-39%，实现小制剂质量的供应。</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi70KwkAQBtNYiPoO6wOkCOJPK0Gxsol9WL3vzMLeD3fr-5vCBxAGpplZNsMQWJWqGL9VsklsA8ynEiRS_VRjiXBUoOAKMn4qjDg6ygWZC5ukSPMyJUc2oSD5dbPwrBWbn1fN9np59LcWOY2omV-IsLG_d93-OHM4nXf_NF_RaDle</recordid><startdate>20230228</startdate><enddate>20230228</enddate><creator>XU CHENGMIAO</creator><creator>LUO JINWEN</creator><creator>LI SONGXIAN</creator><creator>LIU MEILING</creator><creator>JIANG LIJIAN</creator><creator>JIN HAO</creator><creator>ZHOU YUANHAO</creator><creator>HE LI</creator><creator>LI XIAOWEN</creator><scope>EVB</scope></search><sort><creationdate>20230228</creationdate><title>Small sitagliptin-metformin sustained release tablet and preparation method thereof</title><author>XU CHENGMIAO ; LUO JINWEN ; LI SONGXIAN ; LIU MEILING ; JIANG LIJIAN ; JIN HAO ; ZHOU YUANHAO ; HE LI ; LI XIAOWEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115715768A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>XU CHENGMIAO</creatorcontrib><creatorcontrib>LUO JINWEN</creatorcontrib><creatorcontrib>LI SONGXIAN</creatorcontrib><creatorcontrib>LIU MEILING</creatorcontrib><creatorcontrib>JIANG LIJIAN</creatorcontrib><creatorcontrib>JIN HAO</creatorcontrib><creatorcontrib>ZHOU YUANHAO</creatorcontrib><creatorcontrib>HE LI</creatorcontrib><creatorcontrib>LI XIAOWEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU CHENGMIAO</au><au>LUO JINWEN</au><au>LI SONGXIAN</au><au>LIU MEILING</au><au>JIANG LIJIAN</au><au>JIN HAO</au><au>ZHOU YUANHAO</au><au>HE LI</au><au>LI XIAOWEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Small sitagliptin-metformin sustained release tablet and preparation method thereof</title><date>2023-02-28</date><risdate>2023</risdate><abstract>The invention provides a small sitagliptin-metformin sustained release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations containing organic effective components. The metformin sustained-release tablet comprises a protective layer, a sitagliptin quick-release layer, a sustained-release coating layer and a metformin tablet core from outside to inside, and sitagliptin phosphate is coated on the outer layer of the metformin sustained-release tablet core to form the sitagliptin layer in a film-controlled sustained-release mechanism in a solution form. When the sitagliptin-metformin sustained-release tablet is used as the sitagliptin-metformin sustained-release tablet, the mass can be reduced by 15-39%, and the supply of small preparation mass is realized.
本申请提供一种小型西格列汀-二甲双胍缓释片及其制备方法，属于含有机有效成分的药物制剂品技术领域。从外至内分别为保护层、西格列汀速释层、缓释包衣层和二甲双胍片芯，所述磷酸西格列汀以膜控型缓释机制，采用溶液形式上药包衣于二甲双胍缓释片芯外层形成西格列汀层。将本申请作为西格列汀-二甲双胍缓释片使用，可实现质量下降15-39%，实现小制剂质量的供应。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Small sitagliptin-metformin sustained release tablet and preparation method thereof |
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