Small sitagliptin-metformin sustained release tablet and preparation method thereof

The invention provides a small sitagliptin-metformin sustained release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations containing organic effective components. The metformin sustained-release tablet comprises a protective layer, a sitagliptin quick-release layer, a sustained-release coating layer and a metformin tablet core from outside to inside, and sitagliptin phosphate is coated on the outer layer of the metformin sustained-release tablet core to form the sitagliptin layer in a film-controlled sustained-release mechanism in a solution form. When the sitagliptin-metformin sustained-release tablet is used as the sitagliptin-metformin sustained-release tablet, the mass can be reduced by 15-39%, and the supply of small preparation mass is realized. 本申请提供一种小型西格列汀-二甲双胍缓释片及其制备方法，属于含有机有效成分的药物制剂品技术领域。从外至内分别为保护层、西格列汀速释层、缓释包衣层和二甲双胍片芯，所述磷酸西格列汀以膜控型缓释机制，采用溶液形式上药包衣于二甲双胍缓释片芯外层形成西格列汀层。将本申请作为西格列汀-二甲双胍缓释片使用，可实现质量下降15-39%，实现小制剂质量的供应。