NECTIN-4-SPECIFIC BICYCLIC PEPTIDE LIGANDS AND USES THEREOF

NECTIN-4-SPECIFIC BICYCLIC PEPTIDE LIGANDS AND USES THEREOF

The invention relates to a bicyclotoxin conjugate BT8009 or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the bicyclotoxin conjugate BT8009 and an application of the bicyclotoxin conjugate BT8009. In one embodiment, the pharmaceutical composition comprises BT8009, hi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MANKE LUTZ, WITTY, DEREK, LIM DAVID, WEST, THOMAS, A, DIXON ANDREW KEITH, RIGBY MARK
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a bicyclotoxin conjugate BT8009 or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the bicyclotoxin conjugate BT8009 and an application of the bicyclotoxin conjugate BT8009. In one embodiment, the pharmaceutical composition comprises BT8009, histidine, sucrose, and polysorbate 20. In another embodiment, the pharmaceutical composition is used to treat an advanced solid tumor malignancy associated with the expression of Nectin-4 in a patient, preferably in combination with Nasuliumab. 本发明涉及一种双环毒素缀合物BT8009或其药学上可接受的盐，或其药物组合物及其用途。在一个实施方案中，所述药物组合物包含BT8009、组氨酸、蔗糖和聚山梨酯20。在另一个实施方案中，所述药物组合物用于治疗患者中与Nectin-4表达相关的晚期实体瘤恶性肿瘤，优选地与纳武利尤单抗组合。