Quantitative analysis method for four anions in cream preparation

The invention provides a method for simultaneously determining the content of more than four anions in a cream preparation by adopting a liquid chromatography combined electric fog detector (CAD), the more than four anions comprise chloride ions, nitrate ions, phosphate ions and sulfate ions, and the method is characterized in that the liquid chromatography conditions comprise that a chromatographic column is a C18 column, a column temperature is 25 DEG C, a column temperature is 25 DEG C, a column temperature is 25 DEG C, a column temperature is 25 DEG C, a column temperature is 25 DEG C, a column temperature is 25 DEG C, and a column temperature is 25 DEG C; a mobile phase A is a 10mM n-octylamine aqueous solution, the pH value is adjusted to 4.5 +/-0.5, a mobile phase B is acetonitrile, gradient elution is adopted, and a detector is an electrospray detector (CAD). The determination method provided by the invention can accurately quantify the four anions in the cream preparation, and has the advantages of l