Diterpene compound as well as preparation method and application thereof
The invention relates to the technical field of medical biology, in particular to a diterpenoid compound in tetrastigma hemsleyanum and a preparation method and application thereof.The diterpenoid compound is separated and purified through alcohol extraction, silica gel column chromatography, MCI co...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ZHANG YUE CAO YINXUE YANG CHANGSHUI MAO HAOYU JIANG HOULI |
| description | The invention relates to the technical field of medical biology, in particular to a diterpenoid compound in tetrastigma hemsleyanum and a preparation method and application thereof.The diterpenoid compound is separated and purified through alcohol extraction, silica gel column chromatography, MCI column chromatography and semi-preparative HPLC, the novel diterpenoid compound strophiofimbrins is successfully obtained, the operation method is simple, convenient and rapid, the survival rate of model injured nerve cells PC12 can be remarkably increased, and the diterpenoid compound can be used for preparing a new diterpenoid compound. The compound has a good inhibition effect on PC12 nerve cell apoptosis, has remarkable nerve protection activity and can be applied to preparation of novel nerve protection drugs.
本发明涉及医药生物技术领域，具体涉及宿萼木中一种二萜化合物及其制备方法和应用，采用醇提取、硅胶柱层析、MCI柱层析及半制备HPLC进行分离纯化，成功获得新型二萜化合物strophiofimbrins类，操作方法简便及快速，能够显著提高模型损伤神经细胞PC12的存活率，对PC12神经细胞凋亡有较好的抑制效果，本发明的化合物具有较显著的神经保护活性，能够在制备新型神经保护药物中应用。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN115677520A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN115677520A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN115677520A3</originalsourceid><addsrcrecordid>eNrjZPBwySxJLSpIzUtVSM7PLcgvzUtRSCxWKE_NyQHRBUWpBYlFiSWZ-XkKuaklGflAWZCKgoKczGSIcElGalFqfhoPA2taYk5xKi-U5mZQdHMNcfbQTS3Ij08tLkhMBtpREu_sZ2hoamZubmpk4GhMjBoAwBM0jg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Diterpene compound as well as preparation method and application thereof</title><source>esp@cenet</source><creator>ZHANG YUE ; CAO YINXUE ; YANG CHANGSHUI ; MAO HAOYU ; JIANG HOULI</creator><creatorcontrib>ZHANG YUE ; CAO YINXUE ; YANG CHANGSHUI ; MAO HAOYU ; JIANG HOULI</creatorcontrib><description>The invention relates to the technical field of medical biology, in particular to a diterpenoid compound in tetrastigma hemsleyanum and a preparation method and application thereof.The diterpenoid compound is separated and purified through alcohol extraction, silica gel column chromatography, MCI column chromatography and semi-preparative HPLC, the novel diterpenoid compound strophiofimbrins is successfully obtained, the operation method is simple, convenient and rapid, the survival rate of model injured nerve cells PC12 can be remarkably increased, and the diterpenoid compound can be used for preparing a new diterpenoid compound. The compound has a good inhibition effect on PC12 nerve cell apoptosis, has remarkable nerve protection activity and can be applied to preparation of novel nerve protection drugs.
本发明涉及医药生物技术领域，具体涉及宿萼木中一种二萜化合物及其制备方法和应用，采用醇提取、硅胶柱层析、MCI柱层析及半制备HPLC进行分离纯化，成功获得新型二萜化合物strophiofimbrins类，操作方法简便及快速，能够显著提高模型损伤神经细胞PC12的存活率，对PC12神经细胞凋亡有较好的抑制效果，本发明的化合物具有较显著的神经保护活性，能够在制备新型神经保护药物中应用。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230203&DB=EPODOC&CC=CN&NR=115677520A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230203&DB=EPODOC&CC=CN&NR=115677520A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG YUE</creatorcontrib><creatorcontrib>CAO YINXUE</creatorcontrib><creatorcontrib>YANG CHANGSHUI</creatorcontrib><creatorcontrib>MAO HAOYU</creatorcontrib><creatorcontrib>JIANG HOULI</creatorcontrib><title>Diterpene compound as well as preparation method and application thereof</title><description>The invention relates to the technical field of medical biology, in particular to a diterpenoid compound in tetrastigma hemsleyanum and a preparation method and application thereof.The diterpenoid compound is separated and purified through alcohol extraction, silica gel column chromatography, MCI column chromatography and semi-preparative HPLC, the novel diterpenoid compound strophiofimbrins is successfully obtained, the operation method is simple, convenient and rapid, the survival rate of model injured nerve cells PC12 can be remarkably increased, and the diterpenoid compound can be used for preparing a new diterpenoid compound. The compound has a good inhibition effect on PC12 nerve cell apoptosis, has remarkable nerve protection activity and can be applied to preparation of novel nerve protection drugs.
本发明涉及医药生物技术领域，具体涉及宿萼木中一种二萜化合物及其制备方法和应用，采用醇提取、硅胶柱层析、MCI柱层析及半制备HPLC进行分离纯化，成功获得新型二萜化合物strophiofimbrins类，操作方法简便及快速，能够显著提高模型损伤神经细胞PC12的存活率，对PC12神经细胞凋亡有较好的抑制效果，本发明的化合物具有较显著的神经保护活性，能够在制备新型神经保护药物中应用。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBwySxJLSpIzUtVSM7PLcgvzUtRSCxWKE_NyQHRBUWpBYlFiSWZ-XkKuaklGflAWZCKgoKczGSIcElGalFqfhoPA2taYk5xKi-U5mZQdHMNcfbQTS3Ij08tLkhMBtpREu_sZ2hoamZubmpk4GhMjBoAwBM0jg</recordid><startdate>20230203</startdate><enddate>20230203</enddate><creator>ZHANG YUE</creator><creator>CAO YINXUE</creator><creator>YANG CHANGSHUI</creator><creator>MAO HAOYU</creator><creator>JIANG HOULI</creator><scope>EVB</scope></search><sort><creationdate>20230203</creationdate><title>Diterpene compound as well as preparation method and application thereof</title><author>ZHANG YUE ; CAO YINXUE ; YANG CHANGSHUI ; MAO HAOYU ; JIANG HOULI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115677520A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG YUE</creatorcontrib><creatorcontrib>CAO YINXUE</creatorcontrib><creatorcontrib>YANG CHANGSHUI</creatorcontrib><creatorcontrib>MAO HAOYU</creatorcontrib><creatorcontrib>JIANG HOULI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG YUE</au><au>CAO YINXUE</au><au>YANG CHANGSHUI</au><au>MAO HAOYU</au><au>JIANG HOULI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Diterpene compound as well as preparation method and application thereof</title><date>2023-02-03</date><risdate>2023</risdate><abstract>The invention relates to the technical field of medical biology, in particular to a diterpenoid compound in tetrastigma hemsleyanum and a preparation method and application thereof.The diterpenoid compound is separated and purified through alcohol extraction, silica gel column chromatography, MCI column chromatography and semi-preparative HPLC, the novel diterpenoid compound strophiofimbrins is successfully obtained, the operation method is simple, convenient and rapid, the survival rate of model injured nerve cells PC12 can be remarkably increased, and the diterpenoid compound can be used for preparing a new diterpenoid compound. The compound has a good inhibition effect on PC12 nerve cell apoptosis, has remarkable nerve protection activity and can be applied to preparation of novel nerve protection drugs.
本发明涉及医药生物技术领域，具体涉及宿萼木中一种二萜化合物及其制备方法和应用，采用醇提取、硅胶柱层析、MCI柱层析及半制备HPLC进行分离纯化，成功获得新型二萜化合物strophiofimbrins类，操作方法简便及快速，能够显著提高模型损伤神经细胞PC12的存活率，对PC12神经细胞凋亡有较好的抑制效果，本发明的化合物具有较显著的神经保护活性，能够在制备新型神经保护药物中应用。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN115677520A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Diterpene compound as well as preparation method and application thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T07%3A06%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZHANG%20YUE&rft.date=2023-02-03&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN115677520A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |