Application of low-dose interleukin 2 in treatment of autism

The invention provides application of low-dose interleukin 2 in treatment of autism. Specifically, the invention provides application of IL-2 or pharmaceutically acceptable salt or ester thereof, and the IL-2 is used for preparing a pharmaceutical composition or preparation for preventing or treating autism. The low dosage of IL-2 can increase social interaction and social field exploration of autism patients and reduce self-modification behaviors. Meanwhile, a low dose of IL-2 can reduce the ratio of Th17/Treg to Tfh/Treg, improve the immune imbalance of autism patients, and finally significantly improve the social communication and communication obstacles, repeated inscription and immune imbalance of autism patients. 本发明提供了低剂量白介素2在治疗孤独症中的应用。具体地，本发明提供了IL-2或其药学上可接受的盐或酯的用途，它被用于制备预防或治疗孤独症药物组合物或制剂。低剂量IL-2能够增加孤独症患者的社会互动和社会领域探索，减少自我修饰行为。同时，低剂量IL-2能够降低Th17/Treg和Tfh/Treg比值，改善孤独症患者的免疫失衡，最终显著改善孤独症患者的社会交往与沟通障碍、重复刻板和免疫失衡。