Safe use of bile acids and salts thereof as enhancers of nasal delivery of drugs

The present disclosure introduces safe and effective pharmaceutical formulations for intranasal delivery. In particular, the present disclosure incorporates bile acids or salts thereof as promoters to exhibit safe clinical applications of improved bioavailability and tissue tolerance. In some embodiments, pharmaceutical formulations comprising bile acids or salts thereof are provided. In some embodiments, the formulations are suitable for and/or configured for intranasal (IN) delivery, methods of producing such formulations, and methods of treating patients using such formulations. The pharmaceutical formulations include bile acids, salts of bile acids, and/or combinations thereof. In some embodiments, a bile acid, a salt of a bile acid, and/or a combination thereof are configured for use as an absorption enhancer. 本公开引入了安全且有效的用于鼻内递送的药物制剂。具体地，本公开引入了胆汁酸或其盐作为促进剂以展示出改善的生物利用度和组织耐受性的安全临床应用。在一些实施方式中，提供了包括胆汁酸或其盐的药物制剂。在一些实施方式中，所述制剂是适合于和/或被配置成用于鼻内(IN)递送，生产这类制剂的方法，和使用这类制剂治疗患者的方法。所述药物制剂包括胆汁酸、胆汁酸的盐和/或其组合。在一些实施方式中，胆汁酸、胆汁酸