Method for preparing high-drug-loading phoxim nanostructure lipid carrier based on microfluidics

The invention discloses a method for preparing a high-drug-loading phoxim nanostructure lipid carrier based on microfluidics, which comprises the following steps of: adopting an oil phase and a water phase which are respectively composed of phoxim, solid lipid, liquid lipid, an anionic surfactant, a nonionic surfactant, a cosurfactant, water and the like; and preparing the phoxim nanostructure lipid carrier in a microfluidic system. The phoxim nanostructure lipid carrier is environmentally friendly, high in drug loading capacity, high in leaf surface residue capacity, stable in preparation and storage and good in control effect, and efficient control of field lepidoptera pests such as prodenia litura is achieved. 本发明公开了一种基于微流控制备高载药的辛硫磷纳米结构脂质载体的方法，采用含有辛硫磷、固体脂质、液体脂质、阴离子表面活性剂、非离子表面活性剂、助表面活性剂、水等组分分别组成的油相和水相，在微流控系统中制备辛硫磷纳米结构脂质载体。本发明有助于制备一种环境友好、高载药量、叶面残留能力强、制备稳定、贮存稳定和防治效果好的辛硫磷纳米结构脂质载体，实现斜纹夜蛾等田间鳞翅目害虫的高效防治。