Anti-GPRC5D antibody as well as preparation method and application thereof

The invention discloses an anti-GPRC5D antibody and a preparation method and application thereof, the antibody comprises a heavy chain variable region and/or a light chain variable region, the heavy chain variable region comprises amino acid sequences as shown in SEQ ID NO: 44 (HCDR1), SEQ ID NO: 99...

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Bibliographische Detailangaben
Hauptverfasser:	LI XIULAN, LI YANAN, WANG PING, NING TINGTING, DONG GUOLIANG, LUO XUEQIN, WEI HAITAO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an anti-GPRC5D antibody and a preparation method and application thereof, the antibody comprises a heavy chain variable region and/or a light chain variable region, the heavy chain variable region comprises amino acid sequences as shown in SEQ ID NO: 44 (HCDR1), SEQ ID NO: 99 (HCDR2) and SEQ ID NO: 100 (HCDR3), and the light chain variable region comprises amino acid sequences as shown in SEQ ID NO: 101 (LCDR1), SAS (LCDR2) and SEQ ID NO: 102 (LCDR3); or the heavy chain variable region comprises amino acid sequences as shown in SEQ ID NO: 29 (HCDR1), SEQ ID NO: 30 (HCDR2) and SEQ ID NO: 31 (HCDR3), and the light chain variable region comprises amino acid sequences as shown in SEQ ID NO: 47 (LCDR1), YAS (LCDR2) and SEQ ID NO: 48 (LCDR3). The anti-GPRC5D antibody has relatively strong binding activity, reaction specificity, species cross reactivity and endocytosis activity, and is suitable for treatment and product development of related diseases such as subsequent cancers. 本发明公开了抗GPRC5D