Refining method of BTK inhibitor

The invention belongs to the field of medicine synthesis, and particularly provides a BTK inhibitor refining method which comprises the following steps: under the catalytic action of quaternary ammonium salt, reacting a compound shown as a formula I with a compound shown as a formula II under the action of an amine compound, and treating by a pulping method to obtain a compound shown as a formula III of the BTK inhibitor. According to the technical scheme, the BTK inhibitor compound shown in the formula III with high purity and high yield can be obtained, the reaction is clean and thorough, no raw material is left, the yield can reach 92%, and the purity can reach 99.4%. In addition, the technical scheme of the invention avoids the use of a microwave synthesis technology and a column chromatography purification technology, and is more simple, convenient and efficient, easy to operate and low in cost, so that the technical scheme is more suitable for expanding industrial production. 本发明属于医药合成领域，具体地提供了一种BTK抑制剂精