Novel acylated insulin analogue

The invention provides a novel acylated insulin analogue, and particularly provides a side chain compound capable of being used for preparing the acylated insulin analogue, the acylated insulin analogue, a pharmaceutical composition of the acylated insulin analogue, pharmaceutical application of the acylated insulin analogue, an administration method of the acylated insulin analogue and a preparation method of the acylated insulin analogue. The acylated insulin analogue disclosed by the invention can be used for treating diabetes mellitus, has the effect of serving as a weekly-acting preparation or a longer-acting insulin preparation, and can be used for treating once a week or at a lower frequency, so that the compliance of a diabetic patient is increased. 本发明提供了一种新型的酰化的胰岛素类似物，具体提供了一种可以用于制备酰化胰岛素类似物的侧链化合物、酰化胰岛素类似物及其药物组合物、制药用途、给药方法和制备方法。本发明的酰化胰岛素类似物可用于治疗糖尿病，具有作为周制剂或更长效的胰岛素制剂的作用，可一周一次或更低频率用于治疗，增加糖尿病患者的顺应性。