Method for continuously synthesizing 1-(4-hydrazino phenyl) methyl-1, 2, 4-triazole
The invention discloses a method for continuously synthesizing 1-(4-hydrazino phenyl) methyl-1, 2, 4-triazole, which comprises the following steps: dissolving 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline hydrochloride and hydrochloric acid in water to obtain a solution containing the 4-[1H-1, 2, 4-tr...
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| creator | ZHANG YONGJUN ZHU YONGHUA WU GUOPING SHEN GANFENG WANG YANYAN WU XINXIN CAO MINGHONG ZHOU WEIGUO |
| description | The invention discloses a method for continuously synthesizing 1-(4-hydrazino phenyl) methyl-1, 2, 4-triazole, which comprises the following steps: dissolving 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline hydrochloride and hydrochloric acid in water to obtain a solution containing the 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline hydrochloride, namely feed liquid A; preparing a sodium nitrite aqueous solution, namely feed liquid B; preparing a sodium sulfite aqueous solution, namely a feed liquid C; the feed liquid A and the feed liquid B are introduced into a first micro-mixer to be mixed to obtain reaction liquid D, the reaction liquid D directly enters a first tubular reactor to be subjected to a reaction, and reaction liquid E containing 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline diazonium salt is obtained; the reaction liquid E and the feed liquid C are introduced into a second micro-mixer to be mixed and then directly enter a second tubular reactor to react, and a reaction liquid F is obtained; and further |
| format | Patent |
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CAO MINGHONG ; ZHOU WEIGUO</creatorcontrib><description>The invention discloses a method for continuously synthesizing 1-(4-hydrazino phenyl) methyl-1, 2, 4-triazole, which comprises the following steps: dissolving 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline hydrochloride and hydrochloric acid in water to obtain a solution containing the 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline hydrochloride, namely feed liquid A; preparing a sodium nitrite aqueous solution, namely feed liquid B; preparing a sodium sulfite aqueous solution, namely a feed liquid C; the feed liquid A and the feed liquid B are introduced into a first micro-mixer to be mixed to obtain reaction liquid D, the reaction liquid D directly enters a first tubular reactor to be subjected to a reaction, and reaction liquid E containing 4-[1H-1, 2, 4-triazole-1-yl methyl] aniline diazonium salt is obtained; the reaction liquid E and the feed liquid C are introduced into a second micro-mixer to be mixed and then directly enter a second tubular reactor to react, and a reaction liquid F is obtained; 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| title | Method for continuously synthesizing 1-(4-hydrazino phenyl) methyl-1, 2, 4-triazole |
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