Cell matrix nerve graft for repairing peripheral nerve injury and preparation method thereof
The invention discloses a cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof. The cell matrix nerve graft comprises an acellular matrix and a scaffold, the acellular matrix is obtained by decellularizing after stem cells are secreted and formed, the acellu...
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| creator | XU LINGCHI WANG SHANSHAN WANG HONGKUI GU XIAOSONG XU LAI QIAN TIANMEI SUN HUALIN GONG LEILEI LEE MI-WON |
| description | The invention discloses a cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof. The cell matrix nerve graft comprises an acellular matrix and a scaffold, the acellular matrix is obtained by decellularizing after stem cells are secreted and formed, the acellular matrix is wrapped around the scaffold, the defects of autologous nerve transplantation repair can be overcome, the immunogenicity of allogeneic cell transplantation repair is avoided, and the survival rate of the autogeneic nerve transplantation repair is increased. The cell matrix nerve graft beneficial to nerve cell proliferation and migration is provided, a microenvironment beneficial to axon growth is established, the purposes of nerve regeneration and function repair are achieved, and a feasible scheme is provided for clinical nerve defect treatment.
本发明公开了一种修复周围神经损伤的细胞基质神经移植物及其制备方法。细胞基质神经移植物包括脱细胞基质及支架，其中脱细胞基质为干细胞分泌形成后脱细胞得到，脱细胞基质包绕在支架周围，能够克服自体神经移植修复的缺点，以及避免同种异体细胞移植修复的免疫原性，提供利于神经细胞增殖和迁移的细胞基质神经移植物，建立一个有利于轴突生 |
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本发明公开了一种修复周围神经损伤的细胞基质神经移植物及其制备方法。细胞基质神经移植物包括脱细胞基质及支架，其中脱细胞基质为干细胞分泌形成后脱细胞得到，脱细胞基质包绕在支架周围，能够克服自体神经移植修复的缺点，以及避免同种异体细胞移植修复的免疫原性，提供利于神经细胞增殖和迁移的细胞基质神经移植物，建立一个有利于轴突生</description><language>chi ; eng</language><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEDICAL OR VETERINARY SCIENCE ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221115&DB=EPODOC&CC=CN&NR=115337458A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221115&DB=EPODOC&CC=CN&NR=115337458A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XU LINGCHI</creatorcontrib><creatorcontrib>WANG SHANSHAN</creatorcontrib><creatorcontrib>WANG HONGKUI</creatorcontrib><creatorcontrib>GU XIAOSONG</creatorcontrib><creatorcontrib>XU LAI</creatorcontrib><creatorcontrib>QIAN TIANMEI</creatorcontrib><creatorcontrib>SUN HUALIN</creatorcontrib><creatorcontrib>GONG LEILEI</creatorcontrib><creatorcontrib>LEE MI-WON</creatorcontrib><title>Cell matrix nerve graft for repairing peripheral nerve injury and preparation method thereof</title><description>The invention discloses a cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof. The cell matrix nerve graft comprises an acellular matrix and a scaffold, the acellular matrix is obtained by decellularizing after stem cells are secreted and formed, the acellular matrix is wrapped around the scaffold, the defects of autologous nerve transplantation repair can be overcome, the immunogenicity of allogeneic cell transplantation repair is avoided, and the survival rate of the autogeneic nerve transplantation repair is increased. The cell matrix nerve graft beneficial to nerve cell proliferation and migration is provided, a microenvironment beneficial to axon growth is established, the purposes of nerve regeneration and function repair are achieved, and a feasible scheme is provided for clinical nerve defect treatment.
本发明公开了一种修复周围神经损伤的细胞基质神经移植物及其制备方法。细胞基质神经移植物包括脱细胞基质及支架，其中脱细胞基质为干细胞分泌形成后脱细胞得到，脱细胞基质包绕在支架周围，能够克服自体神经移植修复的缺点，以及避免同种异体细胞移植修复的免疫原性，提供利于神经细胞增殖和迁移的细胞基质神经移植物，建立一个有利于轴突生</description><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQBuAsDqK-w_kADqUWXSUoTk6OQjnsn_ZKmoRrFH17FfoATt_yzc3NwnsaOKu8KECfoFbZZXJRSZFYVEJLCSqpg7KfkoT-oW_i0FD6NeUsMdCA3MWG8rciuqWZOfYjVpMLsz4dr_a8QYo1xsR3BOTaXoqiKsvdttofyn_OB-HpPFE</recordid><startdate>20221115</startdate><enddate>20221115</enddate><creator>XU LINGCHI</creator><creator>WANG SHANSHAN</creator><creator>WANG HONGKUI</creator><creator>GU XIAOSONG</creator><creator>XU LAI</creator><creator>QIAN TIANMEI</creator><creator>SUN HUALIN</creator><creator>GONG LEILEI</creator><creator>LEE MI-WON</creator><scope>EVB</scope></search><sort><creationdate>20221115</creationdate><title>Cell matrix nerve graft for repairing peripheral nerve injury and preparation method thereof</title><author>XU LINGCHI ; WANG SHANSHAN ; WANG HONGKUI ; GU XIAOSONG ; XU LAI ; QIAN TIANMEI ; SUN HUALIN ; GONG LEILEI ; LEE MI-WON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN115337458A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><toplevel>online_resources</toplevel><creatorcontrib>XU LINGCHI</creatorcontrib><creatorcontrib>WANG SHANSHAN</creatorcontrib><creatorcontrib>WANG HONGKUI</creatorcontrib><creatorcontrib>GU XIAOSONG</creatorcontrib><creatorcontrib>XU LAI</creatorcontrib><creatorcontrib>QIAN TIANMEI</creatorcontrib><creatorcontrib>SUN HUALIN</creatorcontrib><creatorcontrib>GONG LEILEI</creatorcontrib><creatorcontrib>LEE MI-WON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU LINGCHI</au><au>WANG SHANSHAN</au><au>WANG HONGKUI</au><au>GU XIAOSONG</au><au>XU LAI</au><au>QIAN TIANMEI</au><au>SUN HUALIN</au><au>GONG LEILEI</au><au>LEE MI-WON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Cell matrix nerve graft for repairing peripheral nerve injury and preparation method thereof</title><date>2022-11-15</date><risdate>2022</risdate><abstract>The invention discloses a cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof. The cell matrix nerve graft comprises an acellular matrix and a scaffold, the acellular matrix is obtained by decellularizing after stem cells are secreted and formed, the acellular matrix is wrapped around the scaffold, the defects of autologous nerve transplantation repair can be overcome, the immunogenicity of allogeneic cell transplantation repair is avoided, and the survival rate of the autogeneic nerve transplantation repair is increased. The cell matrix nerve graft beneficial to nerve cell proliferation and migration is provided, a microenvironment beneficial to axon growth is established, the purposes of nerve regeneration and function repair are achieved, and a feasible scheme is provided for clinical nerve defect treatment.
本发明公开了一种修复周围神经损伤的细胞基质神经移植物及其制备方法。细胞基质神经移植物包括脱细胞基质及支架，其中脱细胞基质为干细胞分泌形成后脱细胞得到，脱细胞基质包绕在支架周围，能够克服自体神经移植修复的缺点，以及避免同种异体细胞移植修复的免疫原性，提供利于神经细胞增殖和迁移的细胞基质神经移植物，建立一个有利于轴突生</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL |
| title | Cell matrix nerve graft for repairing peripheral nerve injury and preparation method thereof |
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