Natural polysaccharide-based chemical-physical double-crosslinking hydrogel particle as well as preparation and application thereof

The invention relates to a natural polysaccharide-based chemical-physical double-crosslinking hydrogel particle. A preparation method comprises the following steps: fully mixing a carboxymethyl-beta-cyclodextrin solution with 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide to react; then adding a carboxymethyl chitosan solution, mixing, fully stirring and reacting in a magnetic stirrer, and carrying out chemical cross-linking grafting; adding a sodium alginate solution, fully and uniformly mixing, adding a gluconolactone solution, magnetically stirring, mixing and reacting, so that sodium alginate and carboxymethyl chitosan are physically crosslinked; and performing freeze drying and sieving. The insulin sustained-release preparation is prepared from a natural polysaccharide carrier material with good biocompatibility and can be widely applied to oral delivery of drugs. After the insulin is loaded, the sustained release effect is good, the drug release can be controlled, th