Pharmaceutical composition and application thereof, and application of disulfiram and/or salt of disulfiram

The invention relates to the technical field of prevention and treatment of osteoarthritis, in particular to a pharmaceutical composition and application thereof, and application of disulfiram and/or disulfiram salt. The medicine has the functions of protecting cartilage cells, protecting cartilage, relieving cartilage degeneration caused by osteoarthritis, relieving pain symptoms caused by osteoarthritis and reducing the risk of joint replacement. The medicine has at least one of a function of preventing osteoarthritis and a function of treating osteoarthritis. The disulfiram and/or the salt of the disulfiram in the pharmaceutical composition provided by the invention can reduce the risk of joint replacement, can delay the occurrence and progress of osteoarthritis, and can be used for preventing and treating osteoarthritis. 本发明涉及骨关节炎的预防和治疗技术领域，具体涉及一种药物组合物及其应用、双硫仑和/或双硫仑的盐的应用，该药物为具有选自保护软骨细胞的功能、保护软骨的功能、缓解由骨关节炎引起的软骨退变的功能、减轻由骨关节炎引起的疼痛症状的功能、降低关节置换的风险的功能、预防骨关节炎的功能和治疗骨关节炎的功能中的至少一种功能的药物。本发明提供的药物组合物中的双硫仑和/或双硫仑的盐能够降低关节