Screening method of endogenous polypeptide and application of screened polypeptide

The invention belongs to the field of small molecule polypeptides, and particularly relates to a screening method of endogenous polypeptides and application of the screened polypeptides. According to the method, whether the separated and purified endogenous polypeptide possibly has a biological activity function or not is screened at a preferentially investigated position, and the polypeptide of which the precursor protein expression level is closely related to the clinical prognosis of the endometrial cancer patient is screened by adopting a bioinformatics analysis tool. The endogenous polypeptide PDAEP-1 derived from endometrial cancer tissues is obtained through screening and is released into a focus microenvironment in a paracrine manner. The PDAEP-1 polypeptide is taken as a target spot, can become a specific target spot for treating endometrial cancer, especially invasion and metastasis patients, and is applied to research and development of novel biological targeting drugs for treating endometrial canc