Polypeptide inhibitor for treating triple negative breast cancer as well as preparation method and application of polypeptide inhibitor
The invention discloses a polypeptide inhibitor, and the sequence of the polypeptide inhibitor is D-W-Cyclo (isoD-AP-Dap)-E-E-W-G-N-W-V-D-E or Cyclo (isoD-RR-Dap)-D-W-N-A-P-E-E-W-G-N-W-V-D-E. The invention further discloses a preparation method of the polypeptide inhibitor. The invention also provid...
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| creator | LIU JIANBO LI ZIGANG KONG LINGWEI YIN FENG CHEN HAILING ZHAN MEIMIAO |
| description | The invention discloses a polypeptide inhibitor, and the sequence of the polypeptide inhibitor is D-W-Cyclo (isoD-AP-Dap)-E-E-W-G-N-W-V-D-E or Cyclo (isoD-RR-Dap)-D-W-N-A-P-E-E-W-G-N-W-V-D-E. The invention further discloses a preparation method of the polypeptide inhibitor. The invention also provides a preparation method of the polypeptide inhibitor and application of the polypeptide inhibitor in preparation of drugs for interfering MTDH/SND1 compound formation and treating triple negative breast cancer. According to the polypeptide inhibitor disclosed by the invention, a stable polypeptide ring closing method induced by terminal aspartic acid nucleation is introduced, so that a proper binding conformation can be maintained when the polypeptide is bound with a target spot. Experiments prove that the compound has good cell penetrability and serum stability, and shows good anti-tumor activity and extremely low non-specific cytotoxicity in triple negative breast cancer cells.
本发明公开了一种多肽抑制剂，其序列为：D-W-Cyclo(isoD-A |
| format | Patent |
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本发明公开了一种多肽抑制剂，其序列为：D-W-Cyclo(isoD-A</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Polypeptide inhibitor for treating triple negative breast cancer as well as preparation method and application of polypeptide inhibitor |
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