Application of dosappran in preparation of medicine for preventing and treating depression
The invention belongs to the technical field of new application of medicines, and particularly relates to application of doxapran in preparation of a medicine for preventing and treating depression. According to the invention, the depressive symptom resisting effect of doxaplun is evaluated by const...
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| creator | ZHANG JUNRU ZHANG FENGRUI XU HUI CHEN YAN FANG YUNXIA GUO CHENXIN |
| description | The invention belongs to the technical field of new application of medicines, and particularly relates to application of doxapran in preparation of a medicine for preventing and treating depression. According to the invention, the depressive symptom resisting effect of doxaplun is evaluated by constructing a mouse social competitive failure depression model. Results show that the dosapram can significantly improve behavioristics of depression animals, including enhancing the sweet water preference level and prolonging the forced swimming immobility time; high-dose dosapram can obviously improve the content of 5-HT in the brain, reduce the concentration of cortisol and further improve the excitability of animals suffering from depression; the high-dose dosapram can significantly reduce the expression of depression-related protein Iba-1 in the brain of a depression mouse. And moreover, the depression-like relieving effect of dosapram is better than that of the currently common antidepressant drugs, and the dosa |
| format | Patent |
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According to the invention, the depressive symptom resisting effect of doxaplun is evaluated by constructing a mouse social competitive failure depression model. Results show that the dosapram can significantly improve behavioristics of depression animals, including enhancing the sweet water preference level and prolonging the forced swimming immobility time; high-dose dosapram can obviously improve the content of 5-HT in the brain, reduce the concentration of cortisol and further improve the excitability of animals suffering from depression; the high-dose dosapram can significantly reduce the expression of depression-related protein Iba-1 in the brain of a depression mouse. 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| title | Application of dosappran in preparation of medicine for preventing and treating depression |
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