Nimodipine oral solution and preparation method thereof

The invention discloses a nimodipine oral solution and a preparation method thereof. The nimodipine oral solution consists of nimodipine serving as a pharmaceutical active ingredient, disodium glycyrrhizinate serving as a sweetening agent, methylparaben serving as a preservative and other pharmaceut...

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Bibliographische Detailangaben
Hauptverfasser: XIONG MEI, ZHOU XUELAI, ZHU YIFAN, PENG ZHEYANG, FAN MINHUA, TAO YI, AI FANGXIA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a nimodipine oral solution and a preparation method thereof. The nimodipine oral solution consists of nimodipine serving as a pharmaceutical active ingredient, disodium glycyrrhizinate serving as a sweetening agent, methylparaben serving as a preservative and other pharmaceutically acceptable auxiliary materials. The oral solution provided by the invention has good taste and smell and high comprehensive acceptability, and the medication compliance of children and old patients is good; the preparation method of the oral liquid provided by the invention is simple to operate, high in industrial operation feasibility, less in discharge of three wastes, green, environment-friendly, sustainable, beneficial to large-scale industrial production and more suitable for industrialization. 本发明公开了一种尼莫地平口服溶液及其制备方法,由药物活性成分尼莫地平与甜味剂甘草酸二钠、防腐剂羟苯甲酯以及其他药学上可接受的辅料组成。本发明所提供的口服溶液具有良好的口感和气味,综合接受度高,儿童和老年患者的服药顺应性良好;本发明所提供的口服液的制备方法操作简单,工业操作可行性大,三废排放较少,绿色环保可持续,利于大规模工业化生产,更适合工业化。