Pharmaceutical composition of metformin and empagliflozin and preparation method thereof

The invention provides a preparation method of a medicinal composition of metformin and empagliflozin, which comprises the following steps: S1) mixing a part of adhesive with water to obtain an adhesive aqueous solution; mixing the adhesive aqueous solution with empagliflozin to obtain a suspension; mixing the metformin and/or the metformin salt, the filling agent and the remaining adhesive to obtain a dry mixture; and S2) mixing the dry mixture with the suspension, granulating, and drying to obtain the medicinal composition of metformin and empagliflozin. Compared with the prior art, a wet granulation method is adopted, so that empagliflozin is more fully mixed, the process is simpler than that of a fluidized bed, the operation is easy, the quality is controllable, the dissolution is rapid, the stability of the product is improved, the cost is saved, and commercial production is more convenient. 本发明提供了一种二甲双胍与恩格列净的药物组合物的制备方法，包括：S1)将部分粘合剂与水混合，得到粘合剂水溶液；将所述粘合剂水溶液与恩格列净混合，得到混悬液；将二甲双胍和/或二甲双胍盐、填充剂与余下的粘合剂混合，得到干混物；S2)