Vaccine composition for resisting beta coronavirus and application thereof

The invention discloses an anti-beta coronavirus vaccine composition and application thereof, and belongs to the technical field of biology. The anti-beta coronavirus vaccine composition is inoculated through a mucosal pathway, and comprises a novel coronavirus nucleocapsid protein, a phosphodiester skeleton CpG oligodeoxynucleotide, and pharmaceutic adjuvants. Meanwhile, the invention further relates to application of the vaccine composition in production of novel coronavirus resisting drugs. And further provided are methods of vaccinating compositions to induce humoral immune responses and cell-mediated immune responses against coronavirus beta. Through mucosal inoculation, especially intranasal administration, under an adjusted Th1 immune response mode, the anti-N protein cell-mediated immune cross response can be induced, and an anti-N protein cross antibody can be induced. Meanwhile, the vaccine composition preparation provided by the invention has potential safety. 本发明公开了一种抗β属冠状病毒的疫苗组合物及其应用，属于生物技术领域。其中，