3-mercaptoacetylamino-1,5-subsd.2-oxo-axepon derivatives useful as inhibitor of metrix metalloproteinaes

本发明涉及用作基质金属蛋白酶抑制剂的新的3-巯基乙酰氨基-1.5-二取代的-2-氧代-氮杂环庚烷(azepan)衍生物。本发明还要求保护含有所述化合物的药物组合物以及治疗与基质金属蛋白酶抑制作用相关的各种疾病的方法。 The present invention relates to certain novel 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. Pharmaceutical compositions con...

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Hauptverfasser: M.V. PATEL, A.M. WARSHAWSKY, G.A. FLYNN
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creator M.V. PATEL
A.M. WARSHAWSKY
G.A. FLYNN
description 本发明涉及用作基质金属蛋白酶抑制剂的新的3-巯基乙酰氨基-1.5-二取代的-2-氧代-氮杂环庚烷(azepan)衍生物。本发明还要求保护含有所述化合物的药物组合物以及治疗与基质金属蛋白酶抑制作用相关的各种疾病的方法。 The present invention relates to certain novel 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. Pharmaceutical compositions containing said compounds as well as methods of treating various disease states responding to inhibition of matrix metalloproteinase are also claimed herein.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 3-mercaptoacetylamino-1,5-subsd.2-oxo-axepon derivatives useful as inhibitor of metrix metalloproteinaes
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