Selenium-containing benzamide compound as well as synthesis method and application thereof

The invention discloses a selenium-containing benzamide compound and a green synthesis method and application thereof, and the method comprises the following steps: dissolving an indole compound, a benzisoselenazolone compound and a cuprous catalyst in a solvent, carrying out heating reaction, and after the reaction is finished, carrying out column chromatography purification on the reaction system to obtain the selenium-containing benzamide compound. The compound has potential application in preparation of drugs for treating various malignant tumors. The compound especially has good inhibitory activity on human breast cancer MCF-7 cells and human ovarian cancer SKOV-3 cells. The method provided by the invention has the advantages of high atom economy, cheap and easily available raw materials and catalyst, simple operation, good functional group tolerance, and great application value. 本发明公开了一种含硒苯甲酰胺类化合物及其绿色合成方法与应用，所述方法为：将吲哚类化合物、苯并异硒唑酮类化合物和一价铜催化剂溶解于溶剂中，升温反应，反应结束后反应体系经柱层析纯化，得到含硒苯甲酰胺类化合物。这类化合物具有用于制备治疗各种恶性肿瘤药物中的潜