DUB1 gene and application of detection reagent and inhibitor thereof
The invention belongs to the technical field of biological medicines, and particularly relates to a DUB1 gene and application of a detection reagent and an inhibitor thereof. The invention proves that the expression of the DUB1 gene in gastric cancer is increased and is related to low survival rate....
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| creator | JI ZHIPENG ZANG YIFENG ZHOU YAN WANG DEHAI LIU ZIPING JIANG RIXIA WANG TIANSHI LI QUANHUI DING YINLU WANG YUAN LIU BINGTIAN MI YUSHUAI ZHU JIAN GAO ZHUANGLEI |
| description | The invention belongs to the technical field of biological medicines, and particularly relates to a DUB1 gene and application of a detection reagent and an inhibitor thereof. The invention proves that the expression of the DUB1 gene in gastric cancer is increased and is related to low survival rate. Whether a subject suffers from the gastric cancer or not and the risk of suffering from the gastric cancer can be judged by detecting the expression level of the DUB1 gene in the subject. Consumption of DUB1 can inhibit the progress of gastric cancer in vivo and in vitro, so that the treatment of gastric cancer by taking the DUB1 gene as the target spot has better feasibility and generalization performance.
本发明属于生物医药技术领域，具体涉及DUB1基因、其检测试剂和抑制剂的应用。本发明证实了DUB1基因在胃癌中表达升高，并与低生存率相关。通过检测受试者中所述DUB1基因的表达水平，可以判断受试者是否患有胃癌以及患胃癌的风险。DUB1消耗可抑制体内外胃癌的进展，由此可见，以DUB1基因作为靶点进行胃癌的治疗具有较好的可行性及推广性。 |
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本发明属于生物医药技术领域，具体涉及DUB1基因、其检测试剂和抑制剂的应用。本发明证实了DUB1基因在胃癌中表达升高，并与低生存率相关。通过检测受试者中所述DUB1基因的表达水平，可以判断受试者是否患有胃癌以及患胃癌的风险。DUB1消耗可抑制体内外胃癌的进展，由此可见，以DUB1基因作为靶点进行胃癌的治疗具有较好的可行性及推广性。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBxCXUyVEhPzUtVSMxLUUgsKMjJTE4syczPU8hPU0hJLUlNBnOKUhOBikrAijLzMjKTMkvyixRKMlKLUvPTeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYjLQ_JJ4Zz9DQxMLc1NDUwNHY2LUAABFXzIf</recordid><startdate>20220809</startdate><enddate>20220809</enddate><creator>JI ZHIPENG</creator><creator>ZANG YIFENG</creator><creator>ZHOU YAN</creator><creator>WANG DEHAI</creator><creator>LIU ZIPING</creator><creator>JIANG RIXIA</creator><creator>WANG TIANSHI</creator><creator>LI QUANHUI</creator><creator>DING YINLU</creator><creator>WANG YUAN</creator><creator>LIU BINGTIAN</creator><creator>MI YUSHUAI</creator><creator>ZHU JIAN</creator><creator>GAO ZHUANGLEI</creator><scope>EVB</scope></search><sort><creationdate>20220809</creationdate><title>DUB1 gene and application of detection reagent and inhibitor thereof</title><author>JI ZHIPENG ; ZANG YIFENG ; ZHOU YAN ; WANG DEHAI ; LIU ZIPING ; JIANG RIXIA ; WANG TIANSHI ; LI QUANHUI ; DING YINLU ; WANG YUAN ; LIU BINGTIAN ; MI YUSHUAI ; ZHU JIAN ; GAO ZHUANGLEI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114875150A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>JI ZHIPENG</creatorcontrib><creatorcontrib>ZANG YIFENG</creatorcontrib><creatorcontrib>ZHOU YAN</creatorcontrib><creatorcontrib>WANG DEHAI</creatorcontrib><creatorcontrib>LIU ZIPING</creatorcontrib><creatorcontrib>JIANG RIXIA</creatorcontrib><creatorcontrib>WANG TIANSHI</creatorcontrib><creatorcontrib>LI QUANHUI</creatorcontrib><creatorcontrib>DING YINLU</creatorcontrib><creatorcontrib>WANG YUAN</creatorcontrib><creatorcontrib>LIU BINGTIAN</creatorcontrib><creatorcontrib>MI YUSHUAI</creatorcontrib><creatorcontrib>ZHU JIAN</creatorcontrib><creatorcontrib>GAO ZHUANGLEI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JI ZHIPENG</au><au>ZANG YIFENG</au><au>ZHOU YAN</au><au>WANG DEHAI</au><au>LIU ZIPING</au><au>JIANG RIXIA</au><au>WANG TIANSHI</au><au>LI QUANHUI</au><au>DING YINLU</au><au>WANG YUAN</au><au>LIU BINGTIAN</au><au>MI YUSHUAI</au><au>ZHU JIAN</au><au>GAO ZHUANGLEI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DUB1 gene and application of detection reagent and inhibitor thereof</title><date>2022-08-09</date><risdate>2022</risdate><abstract>The invention belongs to the technical field of biological medicines, and particularly relates to a DUB1 gene and application of a detection reagent and an inhibitor thereof. The invention proves that the expression of the DUB1 gene in gastric cancer is increased and is related to low survival rate. Whether a subject suffers from the gastric cancer or not and the risk of suffering from the gastric cancer can be judged by detecting the expression level of the DUB1 gene in the subject. Consumption of DUB1 can inhibit the progress of gastric cancer in vivo and in vitro, so that the treatment of gastric cancer by taking the DUB1 gene as the target spot has better feasibility and generalization performance.
本发明属于生物医药技术领域，具体涉及DUB1基因、其检测试剂和抑制剂的应用。本发明证实了DUB1基因在胃癌中表达升高，并与低生存率相关。通过检测受试者中所述DUB1基因的表达水平，可以判断受试者是否患有胃癌以及患胃癌的风险。DUB1消耗可抑制体内外胃癌的进展，由此可见，以DUB1基因作为靶点进行胃癌的治疗具有较好的可行性及推广性。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | DUB1 gene and application of detection reagent and inhibitor thereof |
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