Oxadiazole transient receptor potential channel inhibitors
The invention relates to an oxadiazole transient receptor potential channel inhibitor. In particular, the present invention relates to compounds of Formula I and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of making and methods of using the compou...
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| creator | LU AIJUN SAFINA BRIAN SHAW DAVID VOLGRAF MATTHEW TERRETT JACK VILLEMOURE, ERIC LAROUCHE-GAUTIER REMI BEAUMIER FRANCOIS CHEN HUIFEN CONSTANTINEAU-FORGET LEA WARD SEAN DERY, MARTIN LEPISSIER LUDOVIC GRAND-MAITRE CHANTAL |
| description | The invention relates to an oxadiazole transient receptor potential channel inhibitor. In particular, the present invention relates to compounds of Formula I and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of making and methods of using the compounds of Formula I as well as pharmaceutical compositions containing the compounds. The compounds are useful in the treatment of diseases and conditions mediated by TRPA1, such as pain.
本发明涉及噁二唑瞬时受体电位通道抑制剂。具体而言，本发明涉及式I化合物及其可药用盐。此外，本发明涉及式I化合物的制备方法和使用其的方法以及含有所述化合物的药物组合物。所述化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛。 |
| format | Patent |
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本发明涉及噁二唑瞬时受体电位通道抑制剂。具体而言，本发明涉及式I化合物及其可药用盐。此外，本发明涉及式I化合物的制备方法和使用其的方法以及含有所述化合物的药物组合物。所述化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220809&DB=EPODOC&CC=CN&NR=114874209A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220809&DB=EPODOC&CC=CN&NR=114874209A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LU AIJUN</creatorcontrib><creatorcontrib>SAFINA BRIAN</creatorcontrib><creatorcontrib>SHAW DAVID</creatorcontrib><creatorcontrib>VOLGRAF MATTHEW</creatorcontrib><creatorcontrib>TERRETT JACK</creatorcontrib><creatorcontrib>VILLEMOURE, ERIC</creatorcontrib><creatorcontrib>LAROUCHE-GAUTIER REMI</creatorcontrib><creatorcontrib>BEAUMIER FRANCOIS</creatorcontrib><creatorcontrib>CHEN HUIFEN</creatorcontrib><creatorcontrib>CONSTANTINEAU-FORGET LEA</creatorcontrib><creatorcontrib>WARD SEAN</creatorcontrib><creatorcontrib>DERY, MARTIN</creatorcontrib><creatorcontrib>LEPISSIER LUDOVIC</creatorcontrib><creatorcontrib>GRAND-MAITRE CHANTAL</creatorcontrib><title>Oxadiazole transient receptor potential channel inhibitors</title><description>The invention relates to an oxadiazole transient receptor potential channel inhibitor. In particular, the present invention relates to compounds of Formula I and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of making and methods of using the compounds of Formula I as well as pharmaceutical compositions containing the compounds. The compounds are useful in the treatment of diseases and conditions mediated by TRPA1, such as pain.
本发明涉及噁二唑瞬时受体电位通道抑制剂。具体而言，本发明涉及式I化合物及其可药用盐。此外，本发明涉及式I化合物的制备方法和使用其的方法以及含有所述化合物的药物组合物。所述化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDyr0hMyUysys9JVSgpSswrzkzNK1EoSk1OLSjJL1IoyC8B8jMTcxSSMxLz8lJzFDLzMjKTMoFyxTwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN7Zz9DQxMLcxMjA0tGYGDUA4e4v-Q</recordid><startdate>20220809</startdate><enddate>20220809</enddate><creator>LU AIJUN</creator><creator>SAFINA BRIAN</creator><creator>SHAW DAVID</creator><creator>VOLGRAF MATTHEW</creator><creator>TERRETT JACK</creator><creator>VILLEMOURE, ERIC</creator><creator>LAROUCHE-GAUTIER REMI</creator><creator>BEAUMIER FRANCOIS</creator><creator>CHEN HUIFEN</creator><creator>CONSTANTINEAU-FORGET LEA</creator><creator>WARD SEAN</creator><creator>DERY, MARTIN</creator><creator>LEPISSIER LUDOVIC</creator><creator>GRAND-MAITRE CHANTAL</creator><scope>EVB</scope></search><sort><creationdate>20220809</creationdate><title>Oxadiazole transient receptor potential channel inhibitors</title><author>LU AIJUN ; SAFINA BRIAN ; SHAW DAVID ; VOLGRAF MATTHEW ; TERRETT JACK ; VILLEMOURE, ERIC ; LAROUCHE-GAUTIER REMI ; BEAUMIER FRANCOIS ; CHEN HUIFEN ; CONSTANTINEAU-FORGET LEA ; WARD SEAN ; DERY, MARTIN ; LEPISSIER LUDOVIC ; GRAND-MAITRE CHANTAL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114874209A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LU AIJUN</creatorcontrib><creatorcontrib>SAFINA BRIAN</creatorcontrib><creatorcontrib>SHAW DAVID</creatorcontrib><creatorcontrib>VOLGRAF MATTHEW</creatorcontrib><creatorcontrib>TERRETT JACK</creatorcontrib><creatorcontrib>VILLEMOURE, ERIC</creatorcontrib><creatorcontrib>LAROUCHE-GAUTIER REMI</creatorcontrib><creatorcontrib>BEAUMIER FRANCOIS</creatorcontrib><creatorcontrib>CHEN HUIFEN</creatorcontrib><creatorcontrib>CONSTANTINEAU-FORGET LEA</creatorcontrib><creatorcontrib>WARD SEAN</creatorcontrib><creatorcontrib>DERY, MARTIN</creatorcontrib><creatorcontrib>LEPISSIER LUDOVIC</creatorcontrib><creatorcontrib>GRAND-MAITRE CHANTAL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LU AIJUN</au><au>SAFINA BRIAN</au><au>SHAW DAVID</au><au>VOLGRAF MATTHEW</au><au>TERRETT JACK</au><au>VILLEMOURE, ERIC</au><au>LAROUCHE-GAUTIER REMI</au><au>BEAUMIER FRANCOIS</au><au>CHEN HUIFEN</au><au>CONSTANTINEAU-FORGET LEA</au><au>WARD SEAN</au><au>DERY, MARTIN</au><au>LEPISSIER LUDOVIC</au><au>GRAND-MAITRE CHANTAL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Oxadiazole transient receptor potential channel inhibitors</title><date>2022-08-09</date><risdate>2022</risdate><abstract>The invention relates to an oxadiazole transient receptor potential channel inhibitor. In particular, the present invention relates to compounds of Formula I and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of making and methods of using the compounds of Formula I as well as pharmaceutical compositions containing the compounds. The compounds are useful in the treatment of diseases and conditions mediated by TRPA1, such as pain.
本发明涉及噁二唑瞬时受体电位通道抑制剂。具体而言，本发明涉及式I化合物及其可药用盐。此外，本发明涉及式I化合物的制备方法和使用其的方法以及含有所述化合物的药物组合物。所述化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Oxadiazole transient receptor potential channel inhibitors |
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