Novel alpha-cyano-beta-amino acrylate compound and synthesis method thereof

According to the preparation method, ammonium salt or amine salt, aromatic aldehyde and an active methylene compound are subjected to a Knoevenagel-Michael cascade reaction to synthesize the alpha-cyano-beta-amino acrylate compound, and the ammonium salt or amine salt is used as a catalyst and is also used as a reaction substrate. According to the present invention, the application range of the reaction substrate is well expanded, 21 beta-amino acrylate compounds are synthesized, and the synthesis of the alpha-cyano-beta-amino acrylate compounds still has the stable performance in the gram-level reaction. The method disclosed by the invention is simple to operate, high in product yield, good in purity, low in production cost and environment-friendly, and has a potential and wide application prospect in the field of organic catalytic synthesis. 本发明公开一种新型的α-氰基-β-氨基丙烯酸酯类化合物及其制备方法：利用铵盐或胺盐、芳香醛和活性亚甲基化合物，通过Knoevenagel-Michael级联反应合成α-氰基-β-氨基丙烯酸酯类化合物，其中，铵盐或胺盐即作为催化剂，又为反应底物。本发明提供的反应底物适用范围得到了很好的拓展，共合成21种β-氨基丙烯酸酯化合物，所述的α-