Preparation method of cationic lipid material DODMA
The invention discloses a cationic lipid material DODMA preparation method, which comprises: taking oleyl alcohol and 3-dimethylamino-1, 2-propylene glycol as raw materials, carrying out an etherification reaction, filtering, concentrating, and purifying to obtain DODMA. The method has the advantage...
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| creator | LIU LAIFU JI MIN ZHOU GUANGMI YU WENYUAN |
| description | The invention discloses a cationic lipid material DODMA preparation method, which comprises: taking oleyl alcohol and 3-dimethylamino-1, 2-propylene glycol as raw materials, carrying out an etherification reaction, filtering, concentrating, and purifying to obtain DODMA. The method has the advantages of simple reaction steps, simple process, fewer by-products, high yield and greatly reduced production cost, and is easy for industrial production.
本发明公开了一种阳离子脂质材料DODMA的制备方法，步骤如下：以油醇和3-二甲氨基-1,2-丙二醇为原料，发生醚化反应，然后经过过滤、浓缩和纯化得到DODMA。该反应步骤简单，工艺简洁，副产物较少，收率高，生产成本大大降低，易于工业化生产。 |
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本发明公开了一种阳离子脂质材料DODMA的制备方法，步骤如下：以油醇和3-二甲氨基-1,2-丙二醇为原料，发生醚化反应，然后经过过滤、浓缩和纯化得到DODMA。该反应步骤简单，工艺简洁，副产物较少，收率高，生产成本大大降低，易于工业化生产。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220805&DB=EPODOC&CC=CN&NR=114853618A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220805&DB=EPODOC&CC=CN&NR=114853618A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU LAIFU</creatorcontrib><creatorcontrib>JI MIN</creatorcontrib><creatorcontrib>ZHOU GUANGMI</creatorcontrib><creatorcontrib>YU WENYUAN</creatorcontrib><title>Preparation method of cationic lipid material DODMA</title><description>The invention discloses a cationic lipid material DODMA preparation method, which comprises: taking oleyl alcohol and 3-dimethylamino-1, 2-propylene glycol as raw materials, carrying out an etherification reaction, filtering, concentrating, and purifying to obtain DODMA. The method has the advantages of simple reaction steps, simple process, fewer by-products, high yield and greatly reduced production cost, and is easy for industrial production.
本发明公开了一种阳离子脂质材料DODMA的制备方法，步骤如下：以油醇和3-二甲氨基-1,2-丙二醇为原料，发生醚化反应，然后经过过滤、浓缩和纯化得到DODMA。该反应步骤简单，工艺简洁，副产物较少，收率高，生产成本大大降低，易于工业化生产。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAOKEotSCxKLMnMz1PITS3JyE9RyE9TSAYLZCYr5GQWZKYo5CaWpBZlJuYouPi7-DryMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ4Zz9DQxMLU2MzQwtHY2LUAADH4SvP</recordid><startdate>20220805</startdate><enddate>20220805</enddate><creator>LIU LAIFU</creator><creator>JI MIN</creator><creator>ZHOU GUANGMI</creator><creator>YU WENYUAN</creator><scope>EVB</scope></search><sort><creationdate>20220805</creationdate><title>Preparation method of cationic lipid material DODMA</title><author>LIU LAIFU ; JI MIN ; ZHOU GUANGMI ; YU WENYUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114853618A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU LAIFU</creatorcontrib><creatorcontrib>JI MIN</creatorcontrib><creatorcontrib>ZHOU GUANGMI</creatorcontrib><creatorcontrib>YU WENYUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU LAIFU</au><au>JI MIN</au><au>ZHOU GUANGMI</au><au>YU WENYUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of cationic lipid material DODMA</title><date>2022-08-05</date><risdate>2022</risdate><abstract>The invention discloses a cationic lipid material DODMA preparation method, which comprises: taking oleyl alcohol and 3-dimethylamino-1, 2-propylene glycol as raw materials, carrying out an etherification reaction, filtering, concentrating, and purifying to obtain DODMA. The method has the advantages of simple reaction steps, simple process, fewer by-products, high yield and greatly reduced production cost, and is easy for industrial production.
本发明公开了一种阳离子脂质材料DODMA的制备方法，步骤如下：以油醇和3-二甲氨基-1,2-丙二醇为原料，发生醚化反应，然后经过过滤、浓缩和纯化得到DODMA。该反应步骤简单，工艺简洁，副产物较少，收率高，生产成本大大降低，易于工业化生产。</abstract><oa>free_for_read</oa></addata></record> |
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| title | Preparation method of cationic lipid material DODMA |
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