Preparation method of cationic lipid material DODMA

The invention discloses a cationic lipid material DODMA preparation method, which comprises: taking oleyl alcohol and 3-dimethylamino-1, 2-propylene glycol as raw materials, carrying out an etherification reaction, filtering, concentrating, and purifying to obtain DODMA. The method has the advantages of simple reaction steps, simple process, fewer by-products, high yield and greatly reduced production cost, and is easy for industrial production. 本发明公开了一种阳离子脂质材料DODMA的制备方法，步骤如下：以油醇和3-二甲氨基-1,2-丙二醇为原料，发生醚化反应，然后经过过滤、浓缩和纯化得到DODMA。该反应步骤简单，工艺简洁，副产物较少，收率高，生产成本大大降低，易于工业化生产。