Recombinant proteinse of a Pakistani Strain of Hepatitis E and their use in diagnostic methods and vaccines

本发明公开了一种戊型肝炎的ORF2片段，其分子量约55千道尔顿，而且该蛋白具有戊型肝炎病毒的开放阅读框2蛋白的氨基酸112作为其氨基端。该ORF2片段具有很高的免疫原性，可以作为诊断免疫测定的抗原以及作为免疫原或疫苗来防止戊型肝炎的感染。本发明还公开了该非全长ORF2片段的编码序列、载体、宿主细胞、应用以及含有该片段的药物组合物。 A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now...

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Bibliographische Detailangaben
Hauptverfasser:	S.A. TSAREV, R.H. PURCELL, S.U. EMERSON
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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