20-amide-(hydroxamic acid)-pregnenolone conjugate and preparation method thereof

20-amide-(hydroxamic acid)-pregnenolone conjugate and preparation method thereof

The invention discloses an amido bond linked 20-amide-(hydroxamic acid)-pregnenolone conjugate, the chemical structure of which is shown in the following formula. The 20-amide-(hydroxamic acid)-pregnenolone conjugate provided by the invention has a remarkable inhibition effect on human breast cancer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHEN HUALONG, HUANG YANMIN, LIU QINZHOU, CUI JIANGUO, LIANG ZHENGHUI, GAN CHUNFANG
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The invention discloses an amido bond linked 20-amide-(hydroxamic acid)-pregnenolone conjugate, the chemical structure of which is shown in the following formula. The 20-amide-(hydroxamic acid)-pregnenolone conjugate provided by the invention has a remarkable inhibition effect on human breast cancer cells (T47d) and human ovarian cancer cells (SKOV3), and can be used for preparing antitumor drugs. 本发明公开了一种酰胺键链接的20-酰胺-(异羟肟酸)-孕烯醇酮类缀合物，其化学结构如下式所示：本发明的20-酰胺-(异羟肟酸)-孕烯醇酮类缀合物对人乳腺癌细胞(T47d)和人卵巢癌细胞(SKOV3)有显著的抑制作用，可以用于制备抗肿瘤药物。