Preparation and application of oleanolic acid derivatives

The invention relates to the field of medicinal chemistry, in particular to three oleanolic acid derivatives capable of inhibiting activity of alpha-glucosidase, the structures of the oleanolic acid derivatives are shown in the specification, and preliminary activity tests prove that part of the oleanolic acid derivatives have remarkable inhibitory activity on alpha-glucosidase and show a relatively strong anti-diabetic effect. The compound provided by the invention is simple to prepare and strong in alpha-glucosidase activity inhibition capability, and provides guidance for research and development of novel anti-diabetic drugs. 本发明涉及药物化学领域，具体涉及三种具有抑制α-葡萄糖苷酶活性的齐墩果酸衍生物，其结构如下所示：初步活性测试证明，本发明中部分化合物对α-葡萄糖苷酶具有显著抑制活性，显示出较强的抗糖尿病作用。本发明涉及的化合物制备简单，抑制α-葡萄糖苷酶活性能力强，为新型抗糖尿病药物的研发提供了指导。