Iridium complex photosensitizer as well as preparation method and application thereof

The invention belongs to the technical field of photodynamic therapy, and discloses an iridium complex photosensitizer as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a ligand fmp, a compound 1 and a compound 2; prepar...

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Hauptverfasser: DOU WEI, HUANG SHANSHAN, QIU JINLIN, LIU WEISHENG, TANG XIAOLIANG, KOU MANCHANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of photodynamic therapy, and discloses an iridium complex photosensitizer as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a ligand fmp, a compound 1 and a compound 2; preparing a ligand psi by using fmp and a compound 1; and finally, preparing the iridium complex photosensitizer by using the ligand psi and a compound 2. The preparation process is simple, the reaction conditions are mild, the yield is high, and large-scale production conditions are provided. The prepared iridium complex photosensitizer is composed of a ring metal ligand, a metal center and an auxiliary ligand containing an N-substituted indole sulfonate structure, the luminous intensity of the iridium complex photosensitizer is enhanced along with the increase of illumination time, and the progress of photodynamic therapy can be monitored. 本发明属于光动力治疗技术领域,本发明公开了一种铱配合物光敏剂及其制备方法与应用。该制备方法包括以下步骤:先制备配体fmp、化合物1和化合物2;再利用fmp和化合