Trazodone artificial hapten, artificial antigen and preparation method and application thereof

Trazodone artificial hapten, artificial antigen and preparation method and application thereof

The invention discloses a trazodone artificial hapten, an artificial antigen as well as a preparation method and application of the artificial hapten and the artificial antigen. The molecular structural formula of the trazodone artificial hapten is as shown in formula (I), and the molecular structur...

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Hauptverfasser: RUAN TIANYU, WANG ZHEN, SHAO YUESHUI
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator RUAN TIANYU
WANG ZHEN
SHAO YUESHUI
description The invention discloses a trazodone artificial hapten, an artificial antigen as well as a preparation method and application of the artificial hapten and the artificial antigen. The molecular structural formula of the trazodone artificial hapten is as shown in formula (I), and the molecular structural formula of the trazodone artificial antigen is as shown in formula (II). The application is the application of the trazodone artificial antigen in preparation of an anti-trazodone antibody. The trazodone artificial hapten maximally retains the characteristic structure of trazodone, has an active group capable of being coupled with carrier protein, and can be used as an antigenic determinant; the further prepared trazodone artificial antigen can be immunized to obtain an anti-trazodone antibody with high affinity, high sensitivity and strong specificity, the titer of immune serum obtained by immunizing a New Zealand white rabbit is very high, and the trazodone artificial antigen can be used for rapid and accurate
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Trazodone artificial hapten, artificial antigen and preparation method and application thereof
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