Furo [3, 2-b] indole derivative as well as synthesis method and application thereof
The invention discloses a furo [3, 2-b] indole derivative as well as a synthesis method and application thereof, and the synthesis method comprises the following specific steps: taking a 2-(2-furyl) arylamine compound protected by tosyl as a raw material, adding an organic solvent, a catalyst, an ox...
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| creator | LI FEIYUE WANG CHENGYU KONG LINGKAI HAN YU GUAN PENGCHENG JIANG YAKUN MA RONG LIU MINGHUI ZHANG TINGHUI ZHU QIMENG |
| description | The invention discloses a furo [3, 2-b] indole derivative as well as a synthesis method and application thereof, and the synthesis method comprises the following specific steps: taking a 2-(2-furyl) arylamine compound protected by tosyl as a raw material, adding an organic solvent, a catalyst, an oxidizing agent and alkali in a protective atmosphere, and performing catalytic synthesis to obtain the furo [3, 2-b] indole derivative as shown in a formula (I). 2-b] indole derivatives. According to the preparation method disclosed by the invention, coupling cyclization of NH and hydrogen at the position 3 of a furan ring is realized under the catalysis of transition metal, and a target product is obtained. Raw materials are simple and easy to obtain; reaction conditions are mild. The invention further discloses application of the furo [3, 2-b] indole derivative shown in the formula (I) in preparation of anti-allergic, anti-tumor, analgesic and anti-inflammatory drugs.
本发明公开了一种呋喃并[3,2-b]吲哚衍生物及其合成方法和应用，该合成方法的具体步骤为：以 |
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本发明公开了一种呋喃并[3,2-b]吲哚衍生物及其合成方法和应用，该合成方法的具体步骤为：以</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220712&DB=EPODOC&CC=CN&NR=114736212A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220712&DB=EPODOC&CC=CN&NR=114736212A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI FEIYUE</creatorcontrib><creatorcontrib>WANG CHENGYU</creatorcontrib><creatorcontrib>KONG LINGKAI</creatorcontrib><creatorcontrib>HAN YU</creatorcontrib><creatorcontrib>GUAN PENGCHENG</creatorcontrib><creatorcontrib>JIANG YAKUN</creatorcontrib><creatorcontrib>MA RONG</creatorcontrib><creatorcontrib>LIU MINGHUI</creatorcontrib><creatorcontrib>ZHANG TINGHUI</creatorcontrib><creatorcontrib>ZHU QIMENG</creatorcontrib><title>Furo [3, 2-b] indole derivative as well as synthesis method and application thereof</title><description>The invention discloses a furo [3, 2-b] indole derivative as well as a synthesis method and application thereof, and the synthesis method comprises the following specific steps: taking a 2-(2-furyl) arylamine compound protected by tosyl as a raw material, adding an organic solvent, a catalyst, an oxidizing agent and alkali in a protective atmosphere, and performing catalytic synthesis to obtain the furo [3, 2-b] indole derivative as shown in a formula (I). 2-b] indole derivatives. According to the preparation method disclosed by the invention, coupling cyclization of NH and hydrogen at the position 3 of a furan ring is realized under the catalysis of transition metal, and a target product is obtained. Raw materials are simple and easy to obtain; reaction conditions are mild. The invention further discloses application of the furo [3, 2-b] indole derivative shown in the formula (I) in preparation of anti-allergic, anti-tumor, analgesic and anti-inflammatory drugs.
本发明公开了一种呋喃并[3,2-b]吲哚衍生物及其合成方法和应用，该合成方法的具体步骤为：以</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAUALM4iPoPz90OScTOUixOLrqJlNi80kDMC3mx4t8bwQ9wOG64m4tz-0wEV70BVd1v4IIlj2AxuclkNyEYhhd6_zW_Qx6RHcMD80gWTCjE6F1fXgpQakIalmI2GM-4-nkh1u3h0hwrjNQhR9NjwNw1Jym3td4pqfb6n-cDl2Q3TQ</recordid><startdate>20220712</startdate><enddate>20220712</enddate><creator>LI FEIYUE</creator><creator>WANG CHENGYU</creator><creator>KONG LINGKAI</creator><creator>HAN YU</creator><creator>GUAN PENGCHENG</creator><creator>JIANG YAKUN</creator><creator>MA RONG</creator><creator>LIU MINGHUI</creator><creator>ZHANG TINGHUI</creator><creator>ZHU QIMENG</creator><scope>EVB</scope></search><sort><creationdate>20220712</creationdate><title>Furo [3, 2-b] indole derivative as well as synthesis method and application thereof</title><author>LI FEIYUE ; WANG CHENGYU ; KONG LINGKAI ; HAN YU ; GUAN PENGCHENG ; JIANG YAKUN ; MA RONG ; LIU MINGHUI ; ZHANG TINGHUI ; ZHU QIMENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114736212A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI FEIYUE</creatorcontrib><creatorcontrib>WANG CHENGYU</creatorcontrib><creatorcontrib>KONG LINGKAI</creatorcontrib><creatorcontrib>HAN YU</creatorcontrib><creatorcontrib>GUAN PENGCHENG</creatorcontrib><creatorcontrib>JIANG YAKUN</creatorcontrib><creatorcontrib>MA RONG</creatorcontrib><creatorcontrib>LIU MINGHUI</creatorcontrib><creatorcontrib>ZHANG TINGHUI</creatorcontrib><creatorcontrib>ZHU QIMENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI FEIYUE</au><au>WANG CHENGYU</au><au>KONG LINGKAI</au><au>HAN YU</au><au>GUAN PENGCHENG</au><au>JIANG YAKUN</au><au>MA RONG</au><au>LIU MINGHUI</au><au>ZHANG TINGHUI</au><au>ZHU QIMENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Furo [3, 2-b] indole derivative as well as synthesis method and application thereof</title><date>2022-07-12</date><risdate>2022</risdate><abstract>The invention discloses a furo [3, 2-b] indole derivative as well as a synthesis method and application thereof, and the synthesis method comprises the following specific steps: taking a 2-(2-furyl) arylamine compound protected by tosyl as a raw material, adding an organic solvent, a catalyst, an oxidizing agent and alkali in a protective atmosphere, and performing catalytic synthesis to obtain the furo [3, 2-b] indole derivative as shown in a formula (I). 2-b] indole derivatives. According to the preparation method disclosed by the invention, coupling cyclization of NH and hydrogen at the position 3 of a furan ring is realized under the catalysis of transition metal, and a target product is obtained. Raw materials are simple and easy to obtain; reaction conditions are mild. The invention further discloses application of the furo [3, 2-b] indole derivative shown in the formula (I) in preparation of anti-allergic, anti-tumor, analgesic and anti-inflammatory drugs.
本发明公开了一种呋喃并[3,2-b]吲哚衍生物及其合成方法和应用，该合成方法的具体步骤为：以</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Furo [3, 2-b] indole derivative as well as synthesis method and application thereof |
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