Cuprous complex with anti-tumor activity as well as preparation method and application of cuprous complex

The invention relates to the technical field of anti-cancer chemical drugs, in particular to a cuprous complex with anti-tumor activity and a preparation method and application of the cuprous complex. The chemical formula of the cuprous complex is [CuL] ClO4, wherein L is 2-(alpha-quinoline methoxy)...

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Bibliographische Detailangaben
Hauptverfasser: YIN CONGCONG, LI BINGJIN, ZHAO JINZHONG, GAO CHUNYAN, DU WEIJUN, GUO DONGDONG, ZHANG YONGPO, HE QING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of anti-cancer chemical drugs, in particular to a cuprous complex with anti-tumor activity and a preparation method and application of the cuprous complex. The chemical formula of the cuprous complex is [CuL] ClO4, wherein L is 2-(alpha-quinoline methoxy) benzaldehyde condensed p-methylaniline Schiff base; according to the preparation method of the Schiff base cuprous complex, the Schiff base cuprous complex is synthesized from a ligand L and bivalent copper salt Cu (ClO4) 2, and copper in the obtained complex is + 1 valence. The Schiff base cuprous complex has good cytotoxic effect and broad-spectrum anticancer activity on four cancer cells HeLa, BGC-823, NCI-H460 and HepG-2, can possibly generate toxic effect on cancer cells in a mode of inducing cell apoptosis, has the toxic effect on normal cells smaller than that of cis-platinum, has potential medicinal value, and can be used for preparing a novel antitumor drug. The compound is expected to be developed into a