Application of valeramide compound as glutamate dehydrogenase inhibitor

The invention provides an application of a valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase (GDH) inhibitor, and particularly provides an application of the valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl)-4-me...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LI CHANGHONG, HAN DONGNA, ZHOU XUE, ZHU QIUSHA, MENG SHI, YUAN YUE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	LI CHANGHONG HAN DONGNA ZHOU XUE ZHU QIUSHA MENG SHI YUAN YUE
description	The invention provides an application of a valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase (GDH) inhibitor, and particularly provides an application of the valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase inhibitor. The compound has an effective inhibition effect on the activity of glutamate dehydrogenase (GDH) under the condition of micromolar concentration, and can be used for preparing a medicine for preventing and treating diseases caused by the GDH. Glutamate dehydrogenase is a mitochondrial enzyme, and is a key enzyme for glutamic acid to enter tricarboxylic acid cycle to generate ATP (adenosine triphosphate). According to the present invention, the functional mutation of GDH is one of the reasons for the generation of the congenital hyperinsulinemia (CHI) in the newborn, and the generation of the functional mutation of GDH in the newborn is t
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN114681447A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN114681447A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN114681447A3</originalsourceid><addsrcrecordid>eNqNyjsOwjAMANAsDKhwB_cAHSIiYK0qPhMTe2USt7WUxFGSInF7Fg7A9Ja3Vbc-Jc8WK0sEmeCNnjIGdgRWQpI1OsACs18rBqwEjpaPyzJTxELAceEXV8k7tZnQF9r_bFR7vTyHe0dJRioJLUWq4_DQ2hzP2phTf_jnfAG0GzSg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Application of valeramide compound as glutamate dehydrogenase inhibitor</title><source>esp@cenet</source><creator>LI CHANGHONG ; HAN DONGNA ; ZHOU XUE ; ZHU QIUSHA ; MENG SHI ; YUAN YUE</creator><creatorcontrib>LI CHANGHONG ; HAN DONGNA ; ZHOU XUE ; ZHU QIUSHA ; MENG SHI ; YUAN YUE</creatorcontrib><description>The invention provides an application of a valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase (GDH) inhibitor, and particularly provides an application of the valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase inhibitor. The compound has an effective inhibition effect on the activity of glutamate dehydrogenase (GDH) under the condition of micromolar concentration, and can be used for preparing a medicine for preventing and treating diseases caused by the GDH. Glutamate dehydrogenase is a mitochondrial enzyme, and is a key enzyme for glutamic acid to enter tricarboxylic acid cycle to generate ATP (adenosine triphosphate). According to the present invention, the functional mutation of GDH is one of the reasons for the generation of the congenital hyperinsulinemia (CHI) in the newborn, and the generation of the functional mutation of GDH in the newborn is t</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220701&DB=EPODOC&CC=CN&NR=114681447A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220701&DB=EPODOC&CC=CN&NR=114681447A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI CHANGHONG</creatorcontrib><creatorcontrib>HAN DONGNA</creatorcontrib><creatorcontrib>ZHOU XUE</creatorcontrib><creatorcontrib>ZHU QIUSHA</creatorcontrib><creatorcontrib>MENG SHI</creatorcontrib><creatorcontrib>YUAN YUE</creatorcontrib><title>Application of valeramide compound as glutamate dehydrogenase inhibitor</title><description>The invention provides an application of a valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase (GDH) inhibitor, and particularly provides an application of the valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase inhibitor. The compound has an effective inhibition effect on the activity of glutamate dehydrogenase (GDH) under the condition of micromolar concentration, and can be used for preparing a medicine for preventing and treating diseases caused by the GDH. Glutamate dehydrogenase is a mitochondrial enzyme, and is a key enzyme for glutamic acid to enter tricarboxylic acid cycle to generate ATP (adenosine triphosphate). According to the present invention, the functional mutation of GDH is one of the reasons for the generation of the congenital hyperinsulinemia (CHI) in the newborn, and the generation of the functional mutation of GDH in the newborn is t</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjsOwjAMANAsDKhwB_cAHSIiYK0qPhMTe2USt7WUxFGSInF7Fg7A9Ja3Vbc-Jc8WK0sEmeCNnjIGdgRWQpI1OsACs18rBqwEjpaPyzJTxELAceEXV8k7tZnQF9r_bFR7vTyHe0dJRioJLUWq4_DQ2hzP2phTf_jnfAG0GzSg</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>LI CHANGHONG</creator><creator>HAN DONGNA</creator><creator>ZHOU XUE</creator><creator>ZHU QIUSHA</creator><creator>MENG SHI</creator><creator>YUAN YUE</creator><scope>EVB</scope></search><sort><creationdate>20220701</creationdate><title>Application of valeramide compound as glutamate dehydrogenase inhibitor</title><author>LI CHANGHONG ; HAN DONGNA ; ZHOU XUE ; ZHU QIUSHA ; MENG SHI ; YUAN YUE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114681447A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI CHANGHONG</creatorcontrib><creatorcontrib>HAN DONGNA</creatorcontrib><creatorcontrib>ZHOU XUE</creatorcontrib><creatorcontrib>ZHU QIUSHA</creatorcontrib><creatorcontrib>MENG SHI</creatorcontrib><creatorcontrib>YUAN YUE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI CHANGHONG</au><au>HAN DONGNA</au><au>ZHOU XUE</au><au>ZHU QIUSHA</au><au>MENG SHI</au><au>YUAN YUE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of valeramide compound as glutamate dehydrogenase inhibitor</title><date>2022-07-01</date><risdate>2022</risdate><abstract>The invention provides an application of a valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase (GDH) inhibitor, and particularly provides an application of the valeramide compound (S)-N-(1H-indol-6-yl)-4-methyl-2-(1-oxoisoindol-2-yl)-4-methyl-2-(1-oxoisoindol-2-yl) valeramide as a glutamate dehydrogenase inhibitor. The compound has an effective inhibition effect on the activity of glutamate dehydrogenase (GDH) under the condition of micromolar concentration, and can be used for preparing a medicine for preventing and treating diseases caused by the GDH. Glutamate dehydrogenase is a mitochondrial enzyme, and is a key enzyme for glutamic acid to enter tricarboxylic acid cycle to generate ATP (adenosine triphosphate). According to the present invention, the functional mutation of GDH is one of the reasons for the generation of the congenital hyperinsulinemia (CHI) in the newborn, and the generation of the functional mutation of GDH in the newborn is t</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	chi ; eng
recordid	cdi_epo_espacenet_CN114681447A
source	esp@cenet
subjects	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Application of valeramide compound as glutamate dehydrogenase inhibitor
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A51%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LI%20CHANGHONG&rft.date=2022-07-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN114681447A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true