Tryptophan-containing polypeptide maleimide derivative as well as preparation method and application thereof

The invention relates to a tryptophan-containing polypeptide maleimide derivative as well as a preparation method and application thereof. According to the present invention, the maleimide at the tryptophan No.7 site is achieved for the first time, the operation process is simple, the guiding group does not exist, the site selectivity is high, the reaction is efficient, the compound can be prepared only through one step, the compound can be efficiently connected with the biomolecule group, the large drug research and development prospect is provided, and the new scheme is provided for the research and development of the antitumor drug. 本发明涉及一种含色氨酸多肽马来酰亚胺化衍生物及其制备方法和应用。本发明首次实现了在色氨酸七号位的马来酰亚胺化，操作过程简单，无导向基团，位点选择性高，反应高效，只需一步便可制得，并且该化合物能高效连接生物分子基团，具有较大的药物研发研究前景，为研发抗肿瘤药物提供了新的方案。