Preparation method of allyl alcohol compound
The invention discloses a preparation method of an allyl alcohol compound, and belongs to the field of organic chemistry. Aldehyde 1 and trifluoromethanesulfonic acid alkenyl ester 2 are used as raw materials, in the presence of a nickel/chromium catalyst, a phenanthroline or bipyridine ligand and a...
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| creator | LI TONG JIA RUPING CUI YANGBO LU BINGHUI ZHAO YAN SHI LEI SONG YUMAN HAO ERJUN |
| description | The invention discloses a preparation method of an allyl alcohol compound, and belongs to the field of organic chemistry. Aldehyde 1 and trifluoromethanesulfonic acid alkenyl ester 2 are used as raw materials, in the presence of a nickel/chromium catalyst, a phenanthroline or bipyridine ligand and a proton sacrificial agent, irradiation reaction is performed in an organic solvent, and an allyl alcohol compound 3 is obtained. According to the method, raw materials are easy to obtain, operation is easy, extra photocatalysts, metal reducing agents and additives are not needed, and it is proved that the method has very practical application value in complex molecule synthesis through drug molecule post-modification.
本发明公开了一种烯丙醇类化合物的制备方法，属于有机化学领域。以醛1与三氟甲磺酸烯基酯2为原料，在镍/铬催化剂、菲罗啉类或联吡啶类配体和质子牺牲剂存在下，有机溶剂中照射反应，得到烯丙醇化合物3。本发明方法原料易得，操作简单，无需额外光催化剂、金属还原剂和添加剂，通过药物分子后修饰证明该方法在复杂分子合成中具有非常实用的应用价值。 |
| format | Patent |
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本发明公开了一种烯丙醇类化合物的制备方法，属于有机化学领域。以醛1与三氟甲磺酸烯基酯2为原料，在镍/铬催化剂、菲罗啉类或联吡啶类配体和质子牺牲剂存在下，有机溶剂中照射反应，得到烯丙醇化合物3。本发明方法原料易得，操作简单，无需额外光催化剂、金属还原剂和添加剂，通过药物分子后修饰证明该方法在复杂分子合成中具有非常实用的应用价值。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220607&DB=EPODOC&CC=CN&NR=114591281A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220607&DB=EPODOC&CC=CN&NR=114591281A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI TONG</creatorcontrib><creatorcontrib>JIA RUPING</creatorcontrib><creatorcontrib>CUI YANGBO</creatorcontrib><creatorcontrib>LU BINGHUI</creatorcontrib><creatorcontrib>ZHAO YAN</creatorcontrib><creatorcontrib>SHI LEI</creatorcontrib><creatorcontrib>SONG YUMAN</creatorcontrib><creatorcontrib>HAO ERJUN</creatorcontrib><title>Preparation method of allyl alcohol compound</title><description>The invention discloses a preparation method of an allyl alcohol compound, and belongs to the field of organic chemistry. Aldehyde 1 and trifluoromethanesulfonic acid alkenyl ester 2 are used as raw materials, in the presence of a nickel/chromium catalyst, a phenanthroline or bipyridine ligand and a proton sacrificial agent, irradiation reaction is performed in an organic solvent, and an allyl alcohol compound 3 is obtained. According to the method, raw materials are easy to obtain, operation is easy, extra photocatalysts, metal reducing agents and additives are not needed, and it is proved that the method has very practical application value in complex molecule synthesis through drug molecule post-modification.
本发明公开了一种烯丙醇类化合物的制备方法，属于有机化学领域。以醛1与三氟甲磺酸烯基酯2为原料，在镍/铬催化剂、菲罗啉类或联吡啶类配体和质子牺牲剂存在下，有机溶剂中照射反应，得到烯丙醇化合物3。本发明方法原料易得，操作简单，无需额外光催化剂、金属还原剂和添加剂，通过药物分子后修饰证明该方法在复杂分子合成中具有非常实用的应用价值。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAJKEotSCxKLMnMz1PITS3JyE9RyE9TSMzJqcwBksn5Gfk5Csn5uQX5pXkpPAysaYk5xam8UJqbQdHNNcTZQze1ID8-tbggMTk1L7Uk3tnP0NDE1NLQyMLQ0ZgYNQCm1ynz</recordid><startdate>20220607</startdate><enddate>20220607</enddate><creator>LI TONG</creator><creator>JIA RUPING</creator><creator>CUI YANGBO</creator><creator>LU BINGHUI</creator><creator>ZHAO YAN</creator><creator>SHI LEI</creator><creator>SONG YUMAN</creator><creator>HAO ERJUN</creator><scope>EVB</scope></search><sort><creationdate>20220607</creationdate><title>Preparation method of allyl alcohol compound</title><author>LI TONG ; JIA RUPING ; CUI YANGBO ; LU BINGHUI ; ZHAO YAN ; SHI LEI ; SONG YUMAN ; HAO ERJUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114591281A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LI TONG</creatorcontrib><creatorcontrib>JIA RUPING</creatorcontrib><creatorcontrib>CUI YANGBO</creatorcontrib><creatorcontrib>LU BINGHUI</creatorcontrib><creatorcontrib>ZHAO YAN</creatorcontrib><creatorcontrib>SHI LEI</creatorcontrib><creatorcontrib>SONG YUMAN</creatorcontrib><creatorcontrib>HAO ERJUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI TONG</au><au>JIA RUPING</au><au>CUI YANGBO</au><au>LU BINGHUI</au><au>ZHAO YAN</au><au>SHI LEI</au><au>SONG YUMAN</au><au>HAO ERJUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of allyl alcohol compound</title><date>2022-06-07</date><risdate>2022</risdate><abstract>The invention discloses a preparation method of an allyl alcohol compound, and belongs to the field of organic chemistry. Aldehyde 1 and trifluoromethanesulfonic acid alkenyl ester 2 are used as raw materials, in the presence of a nickel/chromium catalyst, a phenanthroline or bipyridine ligand and a proton sacrificial agent, irradiation reaction is performed in an organic solvent, and an allyl alcohol compound 3 is obtained. According to the method, raw materials are easy to obtain, operation is easy, extra photocatalysts, metal reducing agents and additives are not needed, and it is proved that the method has very practical application value in complex molecule synthesis through drug molecule post-modification.
本发明公开了一种烯丙醇类化合物的制备方法，属于有机化学领域。以醛1与三氟甲磺酸烯基酯2为原料，在镍/铬催化剂、菲罗啉类或联吡啶类配体和质子牺牲剂存在下，有机溶剂中照射反应，得到烯丙醇化合物3。本发明方法原料易得，操作简单，无需额外光催化剂、金属还原剂和添加剂，通过药物分子后修饰证明该方法在复杂分子合成中具有非常实用的应用价值。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Preparation method of allyl alcohol compound |
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