Anti-GRP78 antibodies and methods of use thereof

The present invention relates to isolated antibodies that bind to GRP78. In particular, a composition comprising an anti-GRP78 antigen binding protein for recognizing cancer or tumor cells. Furthermore, in some aspects, the anti-GRP78 antigen binding proteins are useful for tumor/cancer specific delivery of drugs and therapies. In another aspect, the disclosed antigen binding proteins are useful for enhancing radiotherapy in a subject having or suspected of having a cancer or tumor wherein the antigen binding proteins are conjugated to a payload, such as a therapeutic agent, an imaging agent, or a combination thereof. 本发明涉及结合GRP78的分离的抗体。具体而言，包含用于识别癌症或肿瘤细胞的抗GRP78抗原结合蛋白的组合物。此外，在一些方面，该抗GRP78抗原结合蛋白用于药物和治疗的肿瘤/癌症特异性递送。在另一方面，所公开的抗原结合蛋白用于增强患有或疑似患有癌症或肿瘤的受试者的放射治疗，其中该抗原结合蛋白与有效负载例如治疗剂、成像剂或其组合缀合。