2, 3-dihydroquinoline-4-ketone bioactive skeleton as well as synthesis method and application thereof

The invention discloses a 2, 3-dihydroquinoline-4-ketone bioactive skeleton as well as a synthesis method and application thereof, and belongs to the technical field of chemical synthesis. The technical scheme is as follows: the structural formula of a bioactive skeleton of the 2, 3-dihydroquinoline-4-ketone is as follows: in the formula, R1 is any one of nitrogen heterocyclic ring and ethyl; r2 is any one of nitrogen heterocyclic ring and methyl; r3 is any one of a hydrogen atom and a methoxy group; and R4 is any one of aryl, heteroaryl, aliphatic substituent, alpha, beta-unsaturated aryl or alpha, beta-unsaturated aliphatic substituent and alpha, beta-benzyne. The method has the advantages of mild reaction conditions, good substrate universality, step economy, atom economy, high chemical selectivity, few byproducts, high yield, cheap raw materials and the like, and is convenient for industrial application in the future. 本发明公开了一种2,3-二氢喹啉-4-酮生物活性骨架及其合成方法和应用，属于化学合成技术领域。其技术方案为：2，3-二氢喹啉-4-酮生物活性骨架的结构式如下：式中，R1为氮杂环