Application of GSDMD inhibitor in atherosclerosis
The invention relates to application of a GSDMD inhibitor in atherosclerosis, and belongs to the technical field of biological medicine. GSDMD is a key molecule for mediating pyroptosis, and pyroptosis participates in the occurrence and development of atherosclerosis and sepsis diseases. The inventi...
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| creator | JIANG HONG SU ENYONG LIU MING ZHANG BAOLI YU PENG |
| description | The invention relates to application of a GSDMD inhibitor in atherosclerosis, and belongs to the technical field of biological medicine. GSDMD is a key molecule for mediating pyroptosis, and pyroptosis participates in the occurrence and development of atherosclerosis and sepsis diseases. The invention designs a polypeptide inhibitor aiming at GSDMD, the inhibitor can be combined with Caspase1 and caspase4/5/11 to competitively inhibit the shearing effect of the enzymes on GSDMD, so that the GSDMD activation level in atherosclerosis model mouse vascular tissues is obviously inhibited, the vascular inflammation is reduced, and the atherosclerosis progress is inhibited; the GSDMD activation level in spleen tissues of septicopyemia model mice is obviously reduced, the systemic inflammation level is reduced, and the survival rate of the mice is improved. The GSDMD polypeptide inhibitor disclosed by the invention can be used as a potential medicine for preventing and treating atherosclerosis and septicopyemia.
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| title | Application of GSDMD inhibitor in atherosclerosis |
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