Method for determining antibiotics containing beta-lactam nucleus in biological fluid and reagent box

本发明涉及在生物液体中检测具有β-内酰胺核的抗生素的方法，其包括如下步骤：a)用一定量的识别试剂接触确定体积的所述生物液体，并在该识别试剂与所述液体中可能存在的抗生素形成复合物的条件下孵育获得的混合物；b)在参照抗生素与步骤a)中没有反应的鉴定试剂形成复合物的条件下，用至少一种固定在支持物上的参照抗生素与步骤a)获得的混合物接触；和c)测定结合在支持物上的识别试剂的量。本发明的特征在于识别试剂包含获自地衣芽孢杆菌并对具有β-内酰胺核的抗生素敏感的受体BlaR或BlaR-CTD。本发明还公开了通过上述方法在生物液体中检测抗生素的检测试剂盒，其包括至少一种识别试剂和至少一种固定在支持物上的参照抗生...

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Hauptverfasser:	B. GRANIER, J. DEGELAEN, J-M. FRERE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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creator	B. GRANIER J. DEGELAEN J-M. FRERE
description	本发明涉及在生物液体中检测具有β-内酰胺核的抗生素的方法，其包括如下步骤：a)用一定量的识别试剂接触确定体积的所述生物液体，并在该识别试剂与所述液体中可能存在的抗生素形成复合物的条件下孵育获得的混合物；b)在参照抗生素与步骤a)中没有反应的鉴定试剂形成复合物的条件下，用至少一种固定在支持物上的参照抗生素与步骤a)获得的混合物接触；和c)测定结合在支持物上的识别试剂的量。本发明的特征在于识别试剂包含获自地衣芽孢杆菌并对具有β-内酰胺核的抗生素敏感的受体BlaR或BlaR-CTD。本发明还公开了通过上述方法在生物液体中检测抗生素的检测试剂盒，其包括至少一种识别试剂和至少一种固定在支持物上的参照抗生素。 A test kit for detecting an antibiotic or antibiotics containing a -lactam ring in a biological fluid is provided. The test kit includes at least one recognition agent, which is a receptor which specifically binds to antibiotics containing a -lactam ring and is obtained from Bacillus licheniformis. The test kit further contains at least one reference antibiotic immobilized on a solid support.
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GRANIER</creatorcontrib><creatorcontrib>J. DEGELAEN</creatorcontrib><creatorcontrib>J-M. FRERE</creatorcontrib><title>Method for determining antibiotics containing beta-lactam nucleus in biological fluid and reagent box</title><description>本发明涉及在生物液体中检测具有β-内酰胺核的抗生素的方法，其包括如下步骤：a)用一定量的识别试剂接触确定体积的所述生物液体，并在该识别试剂与所述液体中可能存在的抗生素形成复合物的条件下孵育获得的混合物；b)在参照抗生素与步骤a)中没有反应的鉴定试剂形成复合物的条件下，用至少一种固定在支持物上的参照抗生素与步骤a)获得的混合物接触；和c)测定结合在支持物上的识别试剂的量。本发明的特征在于识别试剂包含获自地衣芽孢杆菌并对具有β-内酰胺核的抗生素敏感的受体BlaR或BlaR-CTD。本发明还公开了通过上述方法在生物液体中检测抗生素的检测试剂盒，其包括至少一种识别试剂和至少一种固定在支持物上的参照抗生素。 A test kit for detecting an antibiotic or antibiotics containing a -lactam ring in a biological fluid is provided. The test kit includes at least one recognition agent, which is a receptor which specifically binds to antibiotics containing a -lactam ring and is obtained from Bacillus licheniformis. 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FRERE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1145029CC3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>B. GRANIER</creatorcontrib><creatorcontrib>J. DEGELAEN</creatorcontrib><creatorcontrib>J-M. FRERE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>B. GRANIER</au><au>J. DEGELAEN</au><au>J-M. FRERE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for determining antibiotics containing beta-lactam nucleus in biological fluid and reagent box</title><date>2004-04-07</date><risdate>2004</risdate><abstract>本发明涉及在生物液体中检测具有β-内酰胺核的抗生素的方法，其包括如下步骤：a)用一定量的识别试剂接触确定体积的所述生物液体，并在该识别试剂与所述液体中可能存在的抗生素形成复合物的条件下孵育获得的混合物；b)在参照抗生素与步骤a)中没有反应的鉴定试剂形成复合物的条件下，用至少一种固定在支持物上的参照抗生素与步骤a)获得的混合物接触；和c)测定结合在支持物上的识别试剂的量。本发明的特征在于识别试剂包含获自地衣芽孢杆菌并对具有β-内酰胺核的抗生素敏感的受体BlaR或BlaR-CTD。本发明还公开了通过上述方法在生物液体中检测抗生素的检测试剂盒，其包括至少一种识别试剂和至少一种固定在支持物上的参照抗生素。 A test kit for detecting an antibiotic or antibiotics containing a -lactam ring in a biological fluid is provided. The test kit includes at least one recognition agent, which is a receptor which specifically binds to antibiotics containing a -lactam ring and is obtained from Bacillus licheniformis. The test kit further contains at least one reference antibiotic immobilized on a solid support.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
title	Method for determining antibiotics containing beta-lactam nucleus in biological fluid and reagent box
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