Traceable 5-aminosalicylic acid derivative as well as preparation and application thereof
The invention discloses a traceable 5-aminosalicylic acid derivative. The traceable 5-aminosalicylic acid derivative is formed by connecting 5-aminosalicylic acid and a near-infrared fluorescent probe through an azo bond. Experiments show that the azo bond of the compound is broken under the action...
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| creator | KANG JINGYAN SHI YANPING ZHAO XIAOBO |
| description | The invention discloses a traceable 5-aminosalicylic acid derivative. The traceable 5-aminosalicylic acid derivative is formed by connecting 5-aminosalicylic acid and a near-infrared fluorescent probe through an azo bond. Experiments show that the azo bond of the compound is broken under the action of azo reductase secreted by colonic flora, the anti-colitis drug 5-aminosalicylic acid and the semi-near-infrared fluorescent probe are released, and integration of targeted release and fluorescence monitoring of the 5-aminosalicylic acid in colonic tissues is realized; the method has important significance in promoting accurate and personalized treatment of colitis, and has potential application value in the fields of delivery and release of targeted drugs and visual detection.
本发明公开了一种可示踪的5-氨基水杨酸衍生物，由5-氨基水杨酸和近红外荧光探针通过偶氮键连接。实验表明，该化合物在结肠菌群分泌的偶氮还原酶作用下偶氮键发生断裂，释放抗结肠炎药物5-氨基水杨酸和半近红外荧光探针，实现5-氨基水杨酸在结肠组织中靶向释放与荧光监测一体化，对推动结肠炎的精准、个性化治疗具有重要意义，在靶向药物的传递释放与可视化检测领域有潜在的应用价值。 |
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本发明公开了一种可示踪的5-氨基水杨酸衍生物，由5-氨基水杨酸和近红外荧光探针通过偶氮键连接。实验表明，该化合物在结肠菌群分泌的偶氮还原酶作用下偶氮键发生断裂，释放抗结肠炎药物5-氨基水杨酸和半近红外荧光探针，实现5-氨基水杨酸在结肠组织中靶向释放与荧光监测一体化，对推动结肠炎的精准、个性化治疗具有重要意义，在靶向药物的传递释放与可视化检测领域有潜在的应用价值。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220513&DB=EPODOC&CC=CN&NR=114478493A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220513&DB=EPODOC&CC=CN&NR=114478493A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KANG JINGYAN</creatorcontrib><creatorcontrib>SHI YANPING</creatorcontrib><creatorcontrib>ZHAO XIAOBO</creatorcontrib><title>Traceable 5-aminosalicylic acid derivative as well as preparation and application thereof</title><description>The invention discloses a traceable 5-aminosalicylic acid derivative. The traceable 5-aminosalicylic acid derivative is formed by connecting 5-aminosalicylic acid and a near-infrared fluorescent probe through an azo bond. Experiments show that the azo bond of the compound is broken under the action of azo reductase secreted by colonic flora, the anti-colitis drug 5-aminosalicylic acid and the semi-near-infrared fluorescent probe are released, and integration of targeted release and fluorescence monitoring of the 5-aminosalicylic acid in colonic tissues is realized; the method has important significance in promoting accurate and personalized treatment of colitis, and has potential application value in the fields of delivery and release of targeted drugs and visual detection.
本发明公开了一种可示踪的5-氨基水杨酸衍生物，由5-氨基水杨酸和近红外荧光探针通过偶氮键连接。实验表明，该化合物在结肠菌群分泌的偶氮还原酶作用下偶氮键发生断裂，释放抗结肠炎药物5-氨基水杨酸和半近红外荧光探针，实现5-氨基水杨酸在结肠组织中靶向释放与荧光监测一体化，对推动结肠炎的精准、个性化治疗具有重要意义，在靶向药物的传递释放与可视化检测领域有潜在的应用价值。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIgMKUpMTk1MyklVMNVNzM3Myy9OzMlMrgRihcTkzBSFlNSizLLEksyyVIXEYoXy1JwcEF1QlFqQWAQUzs9TSMxLUUgsKADqgPBLMlKLUvPTeBhY0xJzilN5oTQ3g6Kba4izh25qQX58anEB0Nq81JJ4Zz9DQxMTcwsTS2NHY2LUAADXXTrB</recordid><startdate>20220513</startdate><enddate>20220513</enddate><creator>KANG JINGYAN</creator><creator>SHI YANPING</creator><creator>ZHAO XIAOBO</creator><scope>EVB</scope></search><sort><creationdate>20220513</creationdate><title>Traceable 5-aminosalicylic acid derivative as well as preparation and application thereof</title><author>KANG JINGYAN ; SHI YANPING ; ZHAO XIAOBO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114478493A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KANG JINGYAN</creatorcontrib><creatorcontrib>SHI YANPING</creatorcontrib><creatorcontrib>ZHAO XIAOBO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KANG JINGYAN</au><au>SHI YANPING</au><au>ZHAO XIAOBO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Traceable 5-aminosalicylic acid derivative as well as preparation and application thereof</title><date>2022-05-13</date><risdate>2022</risdate><abstract>The invention discloses a traceable 5-aminosalicylic acid derivative. The traceable 5-aminosalicylic acid derivative is formed by connecting 5-aminosalicylic acid and a near-infrared fluorescent probe through an azo bond. Experiments show that the azo bond of the compound is broken under the action of azo reductase secreted by colonic flora, the anti-colitis drug 5-aminosalicylic acid and the semi-near-infrared fluorescent probe are released, and integration of targeted release and fluorescence monitoring of the 5-aminosalicylic acid in colonic tissues is realized; the method has important significance in promoting accurate and personalized treatment of colitis, and has potential application value in the fields of delivery and release of targeted drugs and visual detection.
本发明公开了一种可示踪的5-氨基水杨酸衍生物，由5-氨基水杨酸和近红外荧光探针通过偶氮键连接。实验表明，该化合物在结肠菌群分泌的偶氮还原酶作用下偶氮键发生断裂，释放抗结肠炎药物5-氨基水杨酸和半近红外荧光探针，实现5-氨基水杨酸在结肠组织中靶向释放与荧光监测一体化，对推动结肠炎的精准、个性化治疗具有重要意义，在靶向药物的传递释放与可视化检测领域有潜在的应用价值。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Traceable 5-aminosalicylic acid derivative as well as preparation and application thereof |
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