Continuous production method and device of amantadine
The invention discloses a continuous production method and device of amantadine, and the method is as follows: uniformly mixed raw materials are continuously fed into a high-viscosity reactor preheated to a certain temperature, the materials rotate along with a stirring shaft in the high-viscosity r...
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| creator | ZHUANG CHENGHAN XU XINLIANG CHEN BENXIANG YANG ZHANGYAN ZHANG WEI TANG WUQI ZHUANG JIANGHAI KIM GEON-SO |
| description | The invention discloses a continuous production method and device of amantadine, and the method is as follows: uniformly mixed raw materials are continuously fed into a high-viscosity reactor preheated to a certain temperature, the materials rotate along with a stirring shaft in the high-viscosity reactor and move to a discharge port along the stirring shaft, and gas generated in the reaction process is discharged through a secondary sublimation material condensation bin; the first-stage condensed material is automatically cleaned and returned to the reactor, the second-stage condensed material is collected and purified to obtain adamantanol, the reacted material is continuously discharged from a discharge port of the reactor, an amantadine crude product is obtained through collection, and the amantadine crude product is treated to obtain an amantadine product. The method is simple to operate, high in product yield and purity, short in reaction time, high in production efficiency and small in equipment and si |
| format | Patent |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Continuous production method and device of amantadine |
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