Application of gene Rnf220 in treatment or diagnosis of mild traumatic brain injury
The invention relates to the technical field of brain injury treatment medicines, and discloses an application of a gene Rnf220 in a medicine for treating mild traumatic brain injury, the medicine acts on the target gene Rnf220 to improve the expression quantity of the Rnf220, and then cognitive rec...
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| creator | CAO SHUQIANG CHEN XIAMENG LI MANRUI LIANG WEIBO |
| description | The invention relates to the technical field of brain injury treatment medicines, and discloses an application of a gene Rnf220 in a medicine for treating mild traumatic brain injury, the medicine acts on the target gene Rnf220 to improve the expression quantity of the Rnf220, and then cognitive recovery of brain injury is promoted; the invention also discloses an application of the gene Rnf220 in preparation of a kit for diagnosing mTBI. The invention finds that cognitive recovery after brain injury is delayed by inhibiting expression of the gene Rnf220, and proves that the gene Rnf220 has an effect of promoting cognitive recovery on mTBI and is expected to be used as a therapeutic target for promoting cognitive recovery of mTBI; the gene Rnf220 can also be used as a marker for diagnosing mTBI.
本发明涉及脑损伤治疗药物技术领域，公开了基因Rnf220(Ring finger protein 220)在治疗轻度创伤性脑损伤的药物中的应用，所述药物通过作用于靶点基因Rnf220而提高Rnf220的表达量，进而促进脑损伤的认知恢复；还公开了基因Rnf220在制备诊断mTBI的试剂盒中的应用。本发明发现抑制基因Rnf220的表达延缓了脑损伤后认知的恢复，证明基因Rnf220对mTBI具有促认知恢复的作用，有望作为mTBI促认知恢 |
| format | Patent |
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本发明涉及脑损伤治疗药物技术领域，公开了基因Rnf220(Ring finger protein 220)在治疗轻度创伤性脑损伤的药物中的应用，所述药物通过作用于靶点基因Rnf220而提高Rnf220的表达量，进而促进脑损伤的认知恢复；还公开了基因Rnf220在制备诊断mTBI的试剂盒中的应用。本发明发现抑制基因Rnf220的表达延缓了脑损伤后认知的恢复，证明基因Rnf220对mTBI具有促认知恢复的作用，有望作为mTBI促认知恢</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220329&DB=EPODOC&CC=CN&NR=114250290A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220329&DB=EPODOC&CC=CN&NR=114250290A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CAO SHUQIANG</creatorcontrib><creatorcontrib>CHEN XIAMENG</creatorcontrib><creatorcontrib>LI MANRUI</creatorcontrib><creatorcontrib>LIANG WEIBO</creatorcontrib><title>Application of gene Rnf220 in treatment or diagnosis of mild traumatic brain injury</title><description>The invention relates to the technical field of brain injury treatment medicines, and discloses an application of a gene Rnf220 in a medicine for treating mild traumatic brain injury, the medicine acts on the target gene Rnf220 to improve the expression quantity of the Rnf220, and then cognitive recovery of brain injury is promoted; the invention also discloses an application of the gene Rnf220 in preparation of a kit for diagnosing mTBI. The invention finds that cognitive recovery after brain injury is delayed by inhibiting expression of the gene Rnf220, and proves that the gene Rnf220 has an effect of promoting cognitive recovery on mTBI and is expected to be used as a therapeutic target for promoting cognitive recovery of mTBI; the gene Rnf220 can also be used as a marker for diagnosing mTBI.
本发明涉及脑损伤治疗药物技术领域，公开了基因Rnf220(Ring finger protein 220)在治疗轻度创伤性脑损伤的药物中的应用，所述药物通过作用于靶点基因Rnf220而提高Rnf220的表达量，进而促进脑损伤的认知恢复；还公开了基因Rnf220在制备诊断mTBI的试剂盒中的应用。本发明发现抑制基因Rnf220的表达延缓了脑损伤后认知的恢复，证明基因Rnf220对mTBI具有促认知恢复的作用，有望作为mTBI促认知恢</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh2LCjIyUxOLMnMz1PIT1NIT81LVQjKSzMyMlDIzFMoKUpNLMlNzStRyC9SSMlMTM_LL84sBinMzcxJAUonluYC9SYrJBUlApVn5mWVFlXyMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLEZKAlJfHOfoaGJkamBkaWBo7GxKgBANZAN4s</recordid><startdate>20220329</startdate><enddate>20220329</enddate><creator>CAO SHUQIANG</creator><creator>CHEN XIAMENG</creator><creator>LI MANRUI</creator><creator>LIANG WEIBO</creator><scope>EVB</scope></search><sort><creationdate>20220329</creationdate><title>Application of gene Rnf220 in treatment or diagnosis of mild traumatic brain injury</title><author>CAO SHUQIANG ; CHEN XIAMENG ; LI MANRUI ; LIANG WEIBO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114250290A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CAO SHUQIANG</creatorcontrib><creatorcontrib>CHEN XIAMENG</creatorcontrib><creatorcontrib>LI MANRUI</creatorcontrib><creatorcontrib>LIANG WEIBO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CAO SHUQIANG</au><au>CHEN XIAMENG</au><au>LI MANRUI</au><au>LIANG WEIBO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of gene Rnf220 in treatment or diagnosis of mild traumatic brain injury</title><date>2022-03-29</date><risdate>2022</risdate><abstract>The invention relates to the technical field of brain injury treatment medicines, and discloses an application of a gene Rnf220 in a medicine for treating mild traumatic brain injury, the medicine acts on the target gene Rnf220 to improve the expression quantity of the Rnf220, and then cognitive recovery of brain injury is promoted; the invention also discloses an application of the gene Rnf220 in preparation of a kit for diagnosing mTBI. The invention finds that cognitive recovery after brain injury is delayed by inhibiting expression of the gene Rnf220, and proves that the gene Rnf220 has an effect of promoting cognitive recovery on mTBI and is expected to be used as a therapeutic target for promoting cognitive recovery of mTBI; the gene Rnf220 can also be used as a marker for diagnosing mTBI.
本发明涉及脑损伤治疗药物技术领域，公开了基因Rnf220(Ring finger protein 220)在治疗轻度创伤性脑损伤的药物中的应用，所述药物通过作用于靶点基因Rnf220而提高Rnf220的表达量，进而促进脑损伤的认知恢复；还公开了基因Rnf220在制备诊断mTBI的试剂盒中的应用。本发明发现抑制基因Rnf220的表达延缓了脑损伤后认知的恢复，证明基因Rnf220对mTBI具有促认知恢复的作用，有望作为mTBI促认知恢</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Application of gene Rnf220 in treatment or diagnosis of mild traumatic brain injury |
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